Osteoinductive bone graft substitutes for spinal fusion - A basic science summary
Osteoinductive bone graft substitutes for spinal fusion - A basic science summary
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DOI：
10.1016/s0030-5898(05)70116-4
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发表时间：
1999-10-01
影响因子：
1.8
通讯作者：
Boden, SD
中科院分区：
文献类型：
--
作者：
Ludwig, SC;Boden, SD
对脊柱融合愈合过程中精确的生物学机制的理解才刚刚开始。目前的分子生物学研究表明，这一过程是多因素的，非常复杂。随着研究脊柱融合生物学的改良动物模型的出现，关于关节融合术背后的基础科学的基本信息已经推进了对该过程的了解。此外，随着局部基因治疗以及骨诱导蛋白和骨诱导载体基质的进步，骨科医生将很快进入一个新的时代，生物操作融合。
An understanding of precise biologic mechanisms at work during spinal fusion healing is just beginning to evolve. Current molecular biology research has shown this process to be multifactorial and extremely complex. With the advent of improved animal models to study the biology of spinal fusion, essential information regarding the basic science behind arthrodesis has advanced knowledge of this process. Moreover, with advances in local gene therapy as well as osteoinductive proteins and osteoinductive carrier matrices, the orthopedic surgeon will soon enter into a new era of biologic manipulation for fusion.