A new cytotoxic polychlorinated sulfolipid from contaminated Adriatic mussels
A new cytotoxic polychlorinated sulfolipid from contaminated Adriatic mussels
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DOI：
10.1016/j.tet.2003.12.072
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发表时间：
2004-08-09
期刊：
影响因子：
2.1
通讯作者：
Poletti, R
中科院分区：
文献类型：
--
作者：
Ciminiello, P;Dell'Aversano, C;Poletti, R
通过对 2000 年 10 月在亚得里亚海收集的有毒贝类进行详细分析，我们分离出了一种新的细胞毒性氯磺脂 (3)。其总体结构已通过广泛的 NMR 分析（包括各种 2D 技术）得以阐明；应用村田方法解决了相对立体化学问题。化合物 3 显示出对 WEHI 164 和 J774 细胞具有细胞毒活性。亚得里亚海北部有毒贻贝中氯磺脂的存在绝非偶然，因为我们自 1998 年以来一直在检测这些细胞毒性化合物。它们与典型海洋生物毒素的同时和持续存在对消费者的健康和水产养殖的经济收益构成了进一步的风险。 (C) 2004 Elsevier Ltd. 保留所有权利。
A detailed analysis of toxic shellfish collected in the Adriatic sea in October 2000 allowed us to isolate a new cytotoxic chlorosulfolipid (3). Its gross structure has been elucidated through an extensive NMR analysis including various 2D techniques; the relative stereochemistry has been solved by applying the Murata's method. Compound 3 showed to posses cytotoxic activity against WEHI 164 and J774 cells. The presence of chlorosulfolipids in toxic mussels from the northern Adriatic sea has not to be considered incidental as we have been detecting these cytotoxic compounds since 1998. Their simultaneous and constant presence together with typical marine biotoxins represents a further risk both to consumers' health and aquacultures economic proceeds. (C) 2004 Elsevier Ltd. All rights reserved.