Thiol-ene/acrylate substrates for softening intracortical electrodes.
Thiol-ene/acrylate substrates for softening intracortical electrodes.
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DOI：
10.1002/jbmb.32946
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
T. Ware;Dustin Simon;Clive Liu;Tabassum Musa;Srikanth Vasudevan;Andrew Sloan;E. Keefer;R. Rennaker;W. Voit
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文献类型：
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作者：
T. Ware;Dustin Simon;Clive Liu;Tabassum Musa;Srikanth Vasudevan;Andrew Sloan;E. Keefer;R. Rennaker;W. Voit
神经接口传统上是在刚性和平面基底上制造的，包括硅和工程热塑性塑料。然而，与这些设备相互作用的神经组织是 3D 且高度顺应的。生物-非生物界面的机械失配预计将有助于限制慢性信号记录和刺激的组织反应。在这项工作中，新型三元硫醇烯/丙烯酸酯聚合物网络用于创建神经记录电极的软化基底。通过差示扫描量热法和暴露生理条件前后的动态力学分析来研究基材的热机械性能。该基质系统在暴露于生理条件下时从超过 1 GPa 软化至 18 MPa：达到体温并吸收少于 3% 的液体。在这些基板上制作的电镀铂黑的 177 µm(2) 金电极的阻抗在 1 kHz 时测得为 206 kΩ。具体来说，皮质内电极被制造、植入并用于记录驱动的神经活动。这项工作描述了第一个基质系统，它可以利用光刻的全部功能，通过插入后显着软化来响应生理条件，并记录驱动的神经活动长达 4 周。
Neural interfaces have traditionally been fabricated on rigid and planar substrates, including silicon and engineering thermoplastics. However, the neural tissue with which these devices interact is both 3D and highly compliant. The mechanical mismatch at the biotic-abiotic interface is expected to contribute to the tissue response that limits chronic signal recording and stimulation. In this work, novel ternary thiol-ene/acrylate polymer networks are used to create softening substrates for neural recording electrodes. Thermomechanical properties of the substrates are studied through differential scanning calorimetry and dynamic mechanical analysis both before and after exposure physiological conditions. This substrate system softens from more than 1 GPa to 18 MPa on exposure to physiological conditions: reaching body temperature and taking up less than 3% fluid. The impedance of 177 µm(2) gold electrodes electroplated with platinum black fabricated on these substrates is measured to be 206 kΩ at 1 kHz. Specifically, intracortical electrodes are fabricated, implanted, and used to record driven neural activity. This work describes the first substrate system that can use the full capabilities of photolithography, respond to physiological conditions by softening markedly after insertion, and record driven neural activity for 4 weeks.