Nonhereditary Heterotopic Ossification Implications for Injury, Arthropathy, and Aging
Nonhereditary Heterotopic Ossification Implications for Injury, Arthropathy, and Aging
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DOI：
10.1385/bmm:3:3-4:261
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发表时间：
2005-09-01
影响因子：
1.8
通讯作者：
Foley, Kristin L.
中科院分区：
文献类型：
--
作者：
Pignolo, Robert J.;Foley, Kristin L.
非遗传性异位骨化（NHHO）通常发生在创伤、某些关节病或受伤后，通常是常见的与年龄相关的疾病。在本文中，我们讨论关节周围 NHHO 的病理生理学、诊断和临床表现以及与年龄相关病理学的相关性，以及 NHHO 的预防和治疗。除了 NHHO 发生的诱发事件或临床状况外，主要病因机制仍不清楚。许多形式的 NHHO 在损伤和炎症的背景下发展，这表明骨骼外骨的形成可能与进行性骨化性纤维发育不良中的异位骨化具有相似的起始事件。
Nonhereditary heterotopic ossification (NHHO) usually arises in the setting of trauma, certain arthropathies, or following injury, often in the setting of common age-related conditions. In this article, we discuss the pathophysiology, diagnosis, and clinical findings in periarticular NHHO and the relevance to agerelated pathology, as well as the prevention and treatment of NHHO. Except for the precipitating events or clinical conditions in which NHHO occurs, primary etiological mechanisms remain unknown. Many forms of NHHO develop in the context of injury and inflammation, suggesting that the formation of extraskeletal bone may share similar initiating events with ectopic ossification in fibrodysplasia ossificans progressiva.