T-cell-induced mucosal damage in the intestine
T-cell-induced mucosal damage in the intestine
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DOI：
10.1097/00001574-200411000-00013
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发表时间：
2004-11-01
影响因子：
2.5
通讯作者：
Zhou, PF
中科院分区：
文献类型：
--
作者：
Croitoru, K;Zhou, PF
综述目的T细胞是大多数肠道炎性疾病的核心，特别是乳糜泻、移植物抗宿主病、克罗恩病和溃疡性结肠炎。已经使用体外和体内模型探索了T细胞在这些疾病中促进粘膜损伤的机制。本文将重点介绍最近的研究，旨在了解的机制，其中T细胞参与诱导粘膜damage.Recent的发现最近的研究在体内T细胞活化使用单克隆抗CD 3抗体已经表明，一些细胞毒性T细胞通路是必需的，并参与诱导粘膜损伤，特别是在诱导上皮细胞凋亡。这些包括Fas/FasL和穿孔素途径。T细胞诱导的细胞毒性的其他介质，如TNF α和IFN γ可能有助于粘膜损伤，但不是体内粘膜损伤诱导所必需的。此外，一些研究试图确定的作用，调节粘膜T细胞和生理相关的触发T细胞诱导的mucosal damage.Summary现在很清楚，有显着的冗余机制，导致免疫介导的粘膜损伤，并在体内运作的机制可能无法预测的体外实验。这些调查正在提高我们的免疫介导的肠病的发病机制的理解，并有望导致新的方法来管理这些疾病。
Purpose of review T cells are central to most inflammatory disorders of the intestine, particularly Celiac disease, graft vs. host disease, Crohn disease, and ulcerative colitis. The mechanisms by which T cells contribute to mucosal damage in these disorders have been explored using both in vitro and in vivo models. This review will highlight recent studies directed at understanding the mechanisms by which T cells are involved in the induction of mucosal damage.Recent findings The recent studies of in vivo T-cell activation using monoclonal anti-CD3 antibody have shown that a number of cytotoxic T-cell pathways are required and involved in the induction of mucosal damage and in particular in the induction of epithelial cell apoptosis. These include the Fas/FasL and perforin pathways. Other mediators of T-cell-induced cytotoxicity, such as TNFalpha and IFNgamma may contribute to mucosal damage but are not required for the induction of mucosal damage in vivo. In addition, several studies have tried to identify the role of regulatory mucosal T cells and the physiologically relevant triggers for T-cell-induced mucosal damage.Summary It is now clear that there are significant redundancies in the mechanisms that lead to immune- mediated mucosal damage and that the mechanisms that operate in vivo may not be predicted by in vitro experiments. These investigations are improving our understanding of the pathogenesis of immune-mediated enteropathies and will hopefully lead to new approaches to the management of these disorders.