Synthesis and galectin-binding activities of mercaptododecyl glycosides containing a terminal β-galactosyl group.
Synthesis and galectin-binding activities of mercaptododecyl glycosides containing a terminal β-galactosyl group.
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含有末端β-半乳糖基的巯基十二烷基糖苷的合成和半乳糖凝集素结合活性。
DOI：
10.1016/j.bmcl.2010.12.049
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发表时间：
2011
影响因子：
2.7
通讯作者：
S. Yabuki
中科院分区：
文献类型：
--
作者：
T. Murakami;K. Yoshioka;Yukari Sato;Mutsuo Tanaka;O. Niwa;S. Yabuki
以d-半乳糖或d-乳糖为原料，通过六-O-乙酰基-乳酸（10）作为关键中间体，制备了末端含有β-半乳糖基的巯基十二烷基糖苷。用表面等离子体共振（SPR）方法研究了5种糖脂与6种半乳糖凝集素（β-半乳糖苷结合凝集素）的相互作用。观察到乳糖苷、2-脱氧-乳糖苷和乳糖胺与一些半乳糖凝集素（Gal-3、-4、-8）的高结合反应，而半乳糖苷和2，3-二脱氧-乳糖苷显示低结合活性。
Mercaptododecyl glycosides containing a terminal β-galactosyl group were prepared from d-galactose or from d-lactose via hexa-O-acetyl-lactal (10) as a key intermediate. Interactions of these glycolipids (5 kinds) and galectins (β-galactoside binding lectins, 6 species) were evaluated by surface plasmon resonance (SPR) method. High binding responses were observed for the lactoside, 2-deoxy-lactoside, and lactosaminide with some galectins (Gal-3, -4, -8), whereas the galactoside and 2,3-dideoxy-lactoside showed low binding activities.
来自人肺的多种可溶性 β-半乳糖苷结合凝集素。
DOI：
--
发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Sparrow,CP;Leffler,H;Barondes,SH
通讯作者：
Barondes,SH
DOI：
10.1073/pnas.91.4.1428
发表时间：
1994-02-15
影响因子：
11.1
作者：
LIAO, DI;KAPADIA, G;HERZBERG, O
通讯作者：
HERZBERG, O