Survival, growth and function of damaged cholinergic neurons.
Survival, growth and function of damaged cholinergic neurons.
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受损胆碱能神经元的存活、生长和功能。
DOI：
10.1007/978-3-0348-9138-7_26
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Buzsáki,G
中科院分区：
文献类型：
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作者：
Gage,FH;Tuszynski,MH;Chen,KS;Armstrong,D;Buzsáki,G
最近在确定受损的中枢神经系统胆碱能神经元的生存、生长和功能要求方面取得了进展。特别是，胆碱能神经元对神经生长因子(NGF)在发育、细胞存活、轴突延长和损伤反应中的反应性导致了神经营养假说的提出，这是一个关于神经元对促生长物质的反应性的统一假说。NGF对培养的胆碱能神经元以及隔核、基底核、纹状体和海马区胆碱能神经元的影响，以及NGF防止损伤诱导的细胞死亡和改善衰老效应的能力，为这项工作提供了基础。提出了神经胶质细胞和小胶质细胞在NGF作用中的潜在作用。
Recent progress has been made in defining the requirements for survival, growth and function of damaged cholinergic neurons of the central nervous system. In particular, the responsiveness of cholinergic neurons to nerve growth factor (NGF) in the regulation of development, cell survival, axon elongation, and response to injury has led to the formulation of the Neurotrophic Hypothesis, a unifying hypothesis of neuronal responsiveness to growth-promoting substances. NGF-mediated effects on cholinergic neurons in culture as well as in the septum, basal nucleus, striatum, and hippocampus, and the ability of NGF to prevent lesion-induced cell death and to ameliorate the effects of aging, provide the foundation for this work. A potential role for glia and microglia in mediating the effects of NGF is proposed.