Mammalian GADD34, an apoptosis- and DNA damage-inducible gene
Mammalian GADD34, an apoptosis- and DNA damage-inducible gene
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DOI：
10.1074/jbc.272.21.13731
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发表时间：
1997-05-23
影响因子：
4.8
通讯作者：
Fornace, AJ
中科院分区：
文献类型：
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作者：
Hollander, MC;Zhan, QM;Fornace, AJ
哺乳动物细胞对遗传毒性应激的反应是一个复杂的过程，涉及许多已知的和可能许多未知的基因。电离辐射对人DNA损伤和生长抑制诱导基因GADD 34的诱导作用仅见于某些细胞系，并与电离辐射后的细胞凋亡相关。此外，GADD 34对电离辐射的动力学和剂量反应与凋亡抑制剂BAX的动力学和剂量反应密切相关。然而，与BAX不同，GADD 34反应不依赖于细胞p53状态。GADD 34的羧基末端与两种病毒蛋白的羧基末端具有同源性，已知其中一种病毒蛋白阻止病毒感染细胞的凋亡。GADD 34表达与某些类型的细胞凋亡的关联及其与已知的细胞凋亡调节因子的同源性表明GADD 34也可能在细胞凋亡中起作用。
The mammalian cellular response to genotoxic stress is a complex process involving many known and probably many as yet unknown genes. Induction of the human DNA damage- and growth arrest-inducible gene, GADD34, by ionizing radiation was only seen in certain cell lines and correlated with apoptosis following ionizing radiation. In addition, the kinetics and dose response of GADD34 to ionizing radiation closely paralleled that of the apoptosis inhibitor, BAX. However, unlike BAX, the GADD34 response was independent of cellular p53 status. The carboxyl terminus of GADD34 has homology with the carboxyl termini of two viral proteins, one of which is known to prevent apoptosis of virus infected cells. The association of GADD34 expression with certain types of apoptosis and its homology with a known apoptosis regulator suggests that GADD34 may play a role in apoptosis as well.