Radiation therapy of generalized lymphocytic lymphomas.
Radiation therapy of generalized lymphocytic lymphomas.
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全身性淋巴细胞淋巴瘤的放射治疗。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
R. Johnson
中科院分区：
文献类型：
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作者：
R. Johnson
绝大多数淋巴细胞型恶性淋巴瘤患者在诊断时表现为全身性疾病。随之而来的全身治疗的需要，导致通过化疗作为公认的治疗形式。作为一种替代方案，我们已经调查了“全身放疗”利用全身照射和其他宽场techniques.The经验在这份报告中描述的关注一系列连续的患者入院时全身淋巴结受累。本研究纳入了有文献记载的淋巴瘤侵犯骨髓的病例，而排除了其他淋巴结部位的病例，完全缓解率为93（29例患者中的27例），没有维持治疗的缓解中位持续时间为26个月。放射治疗的疗效与肿瘤细胞的分化程度无关，与肿瘤细胞的分化程度有关。
The overwhelming majority of patients with malignant lymphomas of the lymphocytic type present with generalized disease at the time of diagnosis. The consequent need for systemic therapy has resulted in the adoption of chemotherapy as the accepted form of treatment.As an alternative, we have investigated "systemic radiotherapy" utilizing total body irradiation and other wide-field techniques.The experience described in this report concerns a consecutive series of patients with generalized lymph node involvement on admission. Cases with documented lymphomatous invasion of the bone marrow are included, while those with involvement of other extranodal sites have been excluded from this review.The complete remission rate was 93 per cent (27 of 29 patients) and the median duration of remission without maintenance therapy was 26 months.Following relapse, irradiation was again employed effectively in most instances.Response to therapy was not related to the histologic degree of tumor cell differentiation and was...