Brucellosis in pregnant women
Brucellosis in pregnant women
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DOI：
10.1086/319758
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发表时间：
2001-04-15
影响因子：
11.8
通讯作者：
Memish, ZA
中科院分区：
文献类型：
--
作者：
Khan, MY;Mah, MW;Memish, ZA
布鲁氏菌偶尔会引起人类自然流产，但关于它们是否比其他传染性病原体更频繁地引起流产的理论仍然存在争议。我们回顾了92例在沙特阿拉伯医院就诊的急性布鲁氏菌病孕妇。从1983年到1995年，妊娠和布氏杆菌病的累积发病率为每1000名分娩的产科出院者中有1.3例。早、中期自然流产发生率为43%，晚期宫内死胎发生率为2%。产前应用复方新诺明或复方新诺明/利福平进行抗菌治疗可预防自然流产（相对危险度为0.14; 95%可信区间为0.06-0.37; P <0.0001）。治疗的有益效果发生在发热性疾病的妇女，阴道出血在介绍通常导致自然流产。这项研究表明，自然流产的发生率与布鲁氏菌病的孕妇是高的，这些妇女应该得到及时的抗菌药物治疗时，他们提出的医疗保健。
Brucella species occasionally cause spontaneous human abortion, but theories regarding whether they do so more frequently than do other infectious pathogens remain controversial. We reviewed 92 pregnant women who presented with acute brucellosis at a Saudi Arabian hospital. From 1983 through 1995, the cumulative incidence of pregnancy and brucellosis was 1.3 cases per 1000 delivered obstetrical discharges. The incidence of spontaneous abortion in the first and second trimesters was 43%, and the incidence of intrauterine fetal death in the third trimester was 2%. Antepartum antimicrobial therapy with cotrimoxazole or cotrimoxazole/rifampin was protective against spontaneous abortion (relative risk, 0.14; 95% confidence interval, 0.06-0.37; P < .0001). The beneficial effect of treatment occurred in women with febrile illness; vaginal bleeding at presentation usually led to spontaneous abortion. This study demonstrated that the incidence of spontaneous abortion among pregnant women with brucellosis is high and that these women should receive prompt therapy with antimicrobial agents when they present for medical care.