Bioinspired nanoencapsulation of purple membranes.
Bioinspired nanoencapsulation of purple membranes.
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DOI：
10.1039/b718150g
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发表时间：
2008-05
期刊：
影响因子：
3.4
通讯作者：
Andreas Schönafinger;Sonja Müller;F. Noll;N. Hampp
中科院分区：
文献类型：
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作者：
Andreas Schönafinger;Sonja Müller;F. Noll;N. Hampp
将生物化合物（例如酶或全细胞）包埋在固体宿主材料中似乎是一种有前途的方法，以拓宽其应用领域，使其远远超出自然条件的限制。在医学和生物技术等领域，人们对以微米或纳米尺寸颗粒的形式生产这些类型的复合材料的新方法非常感兴趣。这种方法应适用于大量物质。受自然界的显着特征之一，它的能力，联合收割机（生物）有机和无机成分在纳米尺度的启发，我们开发了一个通用的二氧化硅生物分子封装方法的基础上的概念，吸附层的模板二氧化硅矿化类似于硅藻的生物矿化。应用这种方法的模型物质紫膜（PM）导致在一个定义的混合材料与纳米级的保护封装二氧化硅壳提供了一个高的屏障低分子量分子的扩散。
Embedding biological compounds, e.g. enzymes or whole cells, in solid host material seems to be a promising approach to widen their field of application far beyond the limits of natural conditions. In fields such as medicine and biotechnology, there is great interest in new methods to produce these types of composite materials in the form of micro- or nanosized particles. Such methods should be applicable to large amounts of substance. Inspired by one of nature's remarkable features-its ability to combine (bio)organic and inorganic components at the nanoscale-we developed a generic silica encapsulation method for biomolecules based on the concepts of polyelectrolyte layer adsorption followed by templated silica mineralization similar to biomineralization in diatoms. Application of this method to the model substance purple membrane (PM) resulted in a defined hybrid material with a nanoscale protective encapsulating silica shell providing a high barrier for the diffusion of low molecular weight molecules.