Quality of life predicts one-year survival in patients with implantable cardioverter defibrillators
Quality of life predicts one-year survival in patients with implantable cardioverter defibrillators
复制标题
DOI：
10.1007/s11136-010-9596-6
复制
发表时间：
2010-04-01
影响因子：
3.5
通讯作者：
Thomas, Sue A.
中科院分区：
文献类型：
--
作者：
Kao, Chi-Wen;Friedmann, Erika;Thomas, Sue A.
本研究采用美国国立卫生研究院、国家心肺血液研究所进行的抗心律失常与植入式除颤器（AVID）对照临床试验的数据集，探讨了已知的生存预测因子和生活质量（QOL）对ICD接受者1年生存率的影响。随机分配至ICD治疗组的507例患者被纳入分析。患者大多为男性（78.3%），平均年龄为64.85 ± 10.81岁，平均左心室射血分数为32.2 ± 13.45%。采用健康状况调查问卷（SF-36）和生活质量指数-心脏版（QLI-CV）测量QOL。资料经描述性统计及逻辑回归分析，54例（10.6%）患者于植入ICD后第一年内死亡。血管紧张素转换酶抑制剂（ACE）药物治疗、年龄和QLI-CV是1年生存率的重要独立预测因素。使用ACE药物且QOL良好的年轻患者的生存率大约是未使用ACE药物且QOL较差的老年患者的3倍（OR = 3.96）。生活质量是预测ICD患者1年生存率的重要因素。ACE药物治疗和年轻也预测1年生存率，独立于QOL和彼此。
This study examines the contributions of known predictors of survival and quality of life (QOL) to 1-year survival in ICD recipients.This study used the data set from the antiarrhythmia versus implanted defibrillator (AVID) controlled clinical trial conducted by the National Institutes of Health, National Heart, Lung, and Blood Institute. The 507 patients randomly assigned to the ICD treatment were included in the analysis. Patients were mostly male (78.3%), with mean age of 64.85 +/- A 10.81 and mean left ventricular ejection fraction of 32.2 +/- A 13.45%. QOL was measured with the medical outcomes study 36-item short form health survey (SF-36) and quality of life index-cardiac version (QLI-CV). Data were analyzed with descriptive statistics and logistic regression.Fifty-four (10.6%) patients died in the first year after ICD implantation. Angiotensin-converting enzyme inhibitor (ACE) medication, age, and QLI-CV were significant independent predictors of 1-year survival. The odds of survival of a younger patient with ACE medication and good QOL were approximately three times (OR = 3.96) greater than for an older patient, without ACE medication and with poor QOL.Quality of life is an important factor predicting 1-year survival in patients with ICDs. ACE medication and younger age also predict 1-year survival independent of QOL and each other.