Uterine contractility during the menstrual cycle
Uterine contractility during the menstrual cycle
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DOI：
10.1093/humrep/15.suppl_1.81
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发表时间：
2000-06-01
影响因子：
6.1
通讯作者：
Flamigni, C
中科院分区：
文献类型：
--
作者：
Bulletti, C;de Ziegler, D;Flamigni, C
非妊娠子宫在月经周期中表现出不同的收缩模式。基于非侵入性超声（US）的研究报告重新引起了对子宫收缩力的兴趣。为了阐明子宫收缩力在整个月经周期中发生的变化，我们前瞻性地研究了30名自行车志愿者在六个代表性阶段的子宫收缩（UC）与US和宫内压力（IUP）为基础的方法。结果显示超声和IUP均可测量UC频率。UC振幅和静息压力张力只能通过IUP评估。相反，UC移位的方向只能由US评估。UC的频率增加，在中期周期和整个黄体期下降，表明雌二醇和孕酮发挥积极和消极的作用，子宫收缩力，分别。UC振幅在整个月经周期中增加，在黄体晚期达到最大值。逆行性UC最常见于周期中期，而会聚性（“相反”）UC在黄体期占主导地位。虽然前一种模式确保精子运输，但后者可能有助于胚胎植入。总之，通过US和IUP评估的整个月经周期的UC变化强调子宫收缩力的激素依赖性。虽然有利于精子运输的UC模式似乎受到雌二醇的调节，但子宫静止和着床时聚集UC的优势与孕酮有关。这些数据将有助于识别和治疗子宫收缩力可能的运动障碍性变化，特别是在患有不孕症，子宫内膜异位症和痛经的妇女中。
The non-pregnant uterus shows different patterns of contractility during the menstrual cycle. A renewed interest in uterine contractility has resulted from reports of non-invasive ultrasound (US) based studies. To clarify the changes in uterine contractility occurring throughout the menstrual cycle, we prospectively studied uterine contractions (UC) at six representative stages with US and intrauterine pressure (IUP) based approaches in 30 cycling volunteers. Results showed UC frequency could be measured by either US or IUP. UC amplitude and resting pressure tone could only be assessed by IUP. Conversely, direction of UC displacement could only be assessed by US. UC frequency increased at mid-cycle and decreased throughout the luteal phase suggesting oestradiol and progesterone exert positive and negative actions on uterine contractility, respectively. UC amplitude increased throughout the menstrual cycle to maximum values in the late luteal phase. Retrograde UC were most frequent at mid-cycle and convergent ('opposing') UC predominated during the luteal phase. While the former pattern ensures sperm transport, the latter may facilitate embryo implantation. In conclusion, UC changes throughout the menstrual cycle assessed by US and IUP emphasize the hormonal dependence of uterine contractility. Although UC patterns favouring sperm transport appear regulated by oestradiol, uterine quiescence and the dominance of convergent UC prevailing at the time of implantation are linked to progesterone. These data will serve to identify and treat possible dyskinetic changes in uterine contractility, particularly in women suffering from infertility, endometriosis, and dysmenorrhea.