AIM2 in health and disease: Inflammasome and beyond.
AIM2 in health and disease: Inflammasome and beyond.
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DOI：
10.1111/imr.12903
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发表时间：
2020-09
影响因子：
8.7
通讯作者：
Rathinam VA
中科院分区：
文献类型：
--
作者：
Kumari P;Russo AJ;Shivcharan S;Rathinam VA
Nucleic acid sensing is a critical mechanism by which the immune system monitors for pathogen invasion. A set of germline-encoded innate immune receptors detect microbial DNA in various compartments of the cell, such as endosomes, the cytosol, and the nucleus. Sensing of microbial DNA through these receptors stimulates, in most cases, interferon regulatory factor-dependent type I IFN synthesis followed by JAK/STAT-dependent interferon-stimulated gene expression. In contrast, the detection of DNA in the cytosol by AIM2 assembles a macromolecular complex called the inflammasome, which unleashes the proteolytic activity of a cysteine protease caspase-1. Caspase-1 cleaves and activates the proinflammatory cytokines such as IL-1β and IL18 and a pore-forming protein, gasdermin D, which triggers pyroptosis, an inflammatory form of cell death. Research over the past decade has revealed that AIM2 plays essential roles not only in host defense against pathogens but also in inflammatory diseases, autoimmunity, and cancer in inflammasome-dependent as well as -independent manners. This review discusses the latest advancements in our understanding of AIM2 biology and its functions in health and disease.
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影响因子：
32.4
作者：
de Almeida L;Khare S;Misharin AV;Patel R;Ratsimandresy RA;Wallin MC;Perlman H;Greaves DR;Hoffman HM;Dorfleutner A;Stehlik C
通讯作者：
Stehlik C
DOI：
10.4049/jimmunol.1100381
发表时间：
2011-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fang R;Tsuchiya K;Kawamura I;Shen Y;Hara H;Sakai S;Yamamoto T;Fernandes-Alnemri T;Yang R;Hernandez-Cuellar E;Dewamitta SR;Xu Y;Qu H;Alnemri ES;Mitsuyama M
通讯作者：
Mitsuyama M
影响因子：
30.5
作者：
Buerckstuemmer, Tilmann;Baumann, Christoph;Superti-Furga, Giulio
通讯作者：
Superti-Furga, Giulio
影响因子：
3.1
作者：
Dorfleutner, Andrea;Bryan, Nicole B.;Stehlik, Christian
通讯作者：
Stehlik, Christian
影响因子：
17.1
作者：
Dombrowski Y;Peric M;Koglin S;Kammerbauer C;Göss C;Anz D;Simanski M;Gläser R;Harder J;Hornung V;Gallo RL;Ruzicka T;Besch R;Schauber J
通讯作者：
Schauber J