A Chlorin-Based Nanoscale Metal-Organic Framework for Photodynamic Therapy of Colon Cancers.
A Chlorin-Based Nanoscale Metal-Organic Framework for Photodynamic Therapy of Colon Cancers.
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DOI：
10.1021/jacs.5b04069
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发表时间：
2015-06-24
影响因子：
15
通讯作者：
Lin W
中科院分区：
文献类型：
--
作者：
Lu K;He C;Lin W
我们报道了第一个基于氯的纳米金属有机骨架(NMOF)的合理设计，DBC-UIOO比以前报道的基于卟啉的纳米金属有机骨架DBP-UIOO具有更好的光物理性能。DBP-UIOO中的DBP配体还原为DBC-UIOO中的DBC配体，导致最低能量Q带的消光系数增加11倍，红移13 nm。DBC-UiO继承了DBP-UiO的结晶性、稳定性、孔隙率和纳米板形态，同时由于其改善的光物理特性，DBC-UiO敏化了更有效的1O2生成，并在两个结肠癌小鼠模型上显示出显著增强的光动力疗法(PDT)效果。在DBC-UIO诱导的PDT中，细胞凋亡和免疫原性细胞死亡共同参与了对癌细胞的杀伤。
We report here the rational design of the first chlorin-based nanoscale metal–organic framework (NMOF), DBC-UiO, with much improved photophysical properties over the previously reported porphyrin-based NMOF, DBP-UiO. Reduction of the DBP ligands in DBP-UiO to the DBC ligands in DBC-UiO led to a 13 nm red shift and an 11-fold increase in the extinction coefficient of the lowest-energy Q band. While inheriting the crystallinity, stability, porosity, and nanoplate morphology of DBP-UiO, DBC-UiO sensitizes more efficient 1O2 generation and exhibits significantly enhanced photodynamic therapy (PDT) efficacy on two colon cancer mouse models as a result of its improved photophysical properties. Both apoptosis and immunogenic cell death contributed to killing of cancer cells in DBC-UiO-induced PDT.