Molecular Mechanisms Regulating the Dendritic Development of Newborn Olfactory Bulb Interneurons in a Sensory Experience-Dependent Manner.
Molecular Mechanisms Regulating the Dendritic Development of Newborn Olfactory Bulb Interneurons in a Sensory Experience-Dependent Manner.
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DOI：
10.3389/fnins.2015.00514
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发表时间：
2015
影响因子：
4.3
通讯作者：
Tsuboi A
中科院分区：
文献类型：
--
作者：
Yoshihara S;Takahashi H;Tsuboi A
嗅球中的抑制性中间神经元在整个生命过程中在室管膜下区持续产生，并分化为肾小球周围细胞和颗粒细胞。经历新生嗅球中间神经元重组的神经回路对于气味检测、气味辨别、嗅觉记忆和先天嗅觉反应是必要的。虽然感觉经验已被证明可以调节各种物种和各种结构的发育，包括视网膜，皮层和海马，但对感觉经验如何调节新生嗅球中间神经元的树突发育知之甚少。最近的研究表明，5 T4癌胚滋养层糖蛋白和神经元Per/Arnt/Sim结构域蛋白4（Npas 4）转录因子调节树突分支和树突棘的形成，分别在嗅球中间神经元。在这里，我们总结了感觉输入依赖的新生中间神经元的发展和功能性神经回路的形成在嗅球的分子机制。
Inhibitory interneurons in the olfactory bulb are generated continuously throughout life in the subventricular zone and differentiate into periglomerular and granule cells. Neural circuits that undergo reorganization by newborn olfactory bulb interneurons are necessary for odor detection, odor discrimination, olfactory memory, and innate olfactory responses. Although sensory experience has been shown to regulate development in a variety of species and in various structures, including the retina, cortex, and hippocampus, little is known about how sensory experience regulates the dendritic development of newborn olfactory bulb interneurons. Recent studies revealed that the 5T4 oncofetal trophoblast glycoprotein and the neuronal Per/Arnt/Sim domain protein 4 (Npas4) transcription factor regulate dendritic branching and dendritic spine formation, respectively, in olfactory bulb interneurons. Here, we summarize the molecular mechanisms that underlie the sensory input-dependent development of newborn interneurons and the formation of functional neural circuitry in the olfactory bulb.