A Genome-wide Study Reveals Copy Number Variants Exclusive to Childhood Obesity Cases
A Genome-wide Study Reveals Copy Number Variants Exclusive to Childhood Obesity Cases
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DOI：
10.1016/j.ajhg.2010.09.014
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发表时间：
2010-11-12
影响因子：
9.8
通讯作者：
Grant, Struan F. A.
中科院分区：
文献类型：
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作者：
Glessner, Joseph T.;Bradfield, Jonathan P.;Grant, Struan F. A.
在过去的十年中，美国儿童和成人的肥胖患病率急剧增加。基因组拷贝数变异 (CNV) 与极度肥胖和发育迟缓的受试者密切相关。为了补充这些先前的研究，我们通过检查 BMI 位于前 5 个百分位的儿童来解决常见儿童肥胖症中的 CNV，但排除任何与平均值大于三个标准差的受试者，以减少队列中的严重病例。我们对我们的队列进行了全基因组 CNV 调查。 1080 例定义的欧洲美国人 (EA) 儿童肥胖病例和 2500 例瘦对照（
The prevalence of obesity in children and adults in the United States has increased dramatically over the past decade Genomic copy number variations (CNVs) have been strongly implicated in subjects with extreme obesity and coexisting developmental delay To complement these previous studies, we addressed CNVs in common childhood obesity by examining children with a BMI in the upper 5(th) percentile but excluding any subject greater than three standard deviations from the mean in order to reduce severe cases in the cohort We performed a whole genome CNV survey of our cohort of 1080 defined European American (EA) childhood obesity cases and 2500 lean controls (