FLUCTUATIONS IN ION CHANNEL GATING CURRENTS - ANALYSIS OF NONSTATIONARY SHOT NOISE
FLUCTUATIONS IN ION CHANNEL GATING CURRENTS - ANALYSIS OF NONSTATIONARY SHOT NOISE
复制标题
DOI：
10.1016/s0006-3495(93)81341-9
复制
发表时间：
1993-01-01
影响因子：
3.4
通讯作者：
SIGWORTH, FJ
中科院分区：
文献类型：
--
作者：
CROUZY, SC;SIGWORTH, FJ
Conti and Stuhmer (1989. Eur. Biophys. J. 17:53-59) have measured the nonstationary shot noise in the gating current of a population of sodium channels. Here we present expressions for the autocovariance and variance of such noise from general Markov models of channel kinetics, based on the theoretical work of E. Frehland. We compare the predictions of the independent, two-state gating model used by Conti and Stohmer with a six-state model of sodium channel activation based on the work of Armstrong and Gilly (1979. J. Gen. Physiol. 74:691-711). We find that Conti and Stuhmer's experiment would not be able to distinguish between these schemes. We describe experimental conditions under which better model discrimination would be possible.
