In vitro activity of cefoxitin and imipenem against Mycobacterium abscessus complex
In vitro activity of cefoxitin and imipenem against Mycobacterium abscessus complex
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DOI：
10.1111/1469-0691.12405
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发表时间：
2014-05-01
影响因子：
14.2
通讯作者：
Mainardi, J. -L.
中科院分区：
文献类型：
--
作者：
Lavollay, M.;Dubee, V.;Mainardi, J. -L.
头孢西丁和亚胺培南的体外活性进行了比较43株分枝杆菌复合体，主要是从囊性纤维化患者分离。亚胺培南的MIC低于头孢西丁，尽管根据CLSI折点，亚胺培南耐药菌株的数量较高。菌株比较表明，头孢西丁对博莱分枝杆菌的MIC显著高于对M。你好两种β-内酰胺类药物对粗糙形态型的MIC均高于光滑形态型。亚胺培南和头孢西丁的体外活性差异的临床影响仍有待确定。
The in vitro activity of cefoxitin and imipenem was compared for 43 strains of the Mycobacterium abscessus complex, mostly isolated from cystic fibrosis patients. The MICs of imipenem were lower than those of cefoxitin, although the number of imipenem-resistant strains was higher according to the CLSI breakpoints. Strain comparisons indicated that the MICs of cefoxitin were significantly higher for Mycobacterium bolletii than for M. abscessus. The MICs of both beta-lactams were higher for the rough morphotype than for the smooth morphotype. The clinical impact of the in vitro difference between the activity of imipenem and that of cefoxitin remains to be determined.