Nonalcoholic fatty liver disease and cardiovascular disease
Nonalcoholic fatty liver disease and cardiovascular disease
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DOI：
10.3748/wjg.v20.i26.8407
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发表时间：
2014-07-14
影响因子：
4.3
通讯作者：
Lu, Hong-Yun
中科院分区：
文献类型：
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作者：
Liu, Hong;Lu, Hong-Yun
非酒精性脂肪性肝病（NAFLD）和心血管疾病（CVD）是两种常见于普通人群的疾病。到目前为止，已经进行了许多研究，并证明了NAFLD和CVD之间的直接联系，但这种复杂关系的确切机制还没有很好地建立。PubMed数据库的系统检索显示，NAFLD的许多局部和全身表现涉及几种常见机制，并导致心血管风险增加。NAFLD和CVD之间的可能机制包括炎症、氧化应激、胰岛素抵抗、异位脂肪组织分布、血脂异常、内皮功能障碍和脂联素等。临床意义是NAFLD患者CVD风险增加，应定期进行心血管风险评估。(C)2014百世登出版集团股份有限公司All rights reserved.
Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are two diseases that are common in the general population. To date, many studies have been conducted and demonstrate a direct link between NAFLD and CVD, but the exact mechanisms for this complex relationship are not well established. A systematic search of the PubMed database revealed that several common mechanisms are involved in many of the local and systemic manifestations of NAFLD and lead to an increased cardiovascular risk. The possible mechanisms linking NAFLD and CVD include inflammation, oxidative stress, insulin resistance, ectopic adipose tissue distribution, dyslipidemia, endothelial dysfunction, and adiponectin, among others. The clinical implication is that patients with NAFLD are at an increased risk of CVD and should undergo periodic cardiovascular risk assessment. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.