Fundus changes in central retinal vein occlusion.
Fundus changes in central retinal vein occlusion.
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DOI：
10.1097/iae.0000000000000256
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Zimmerman MB
中科院分区：
文献类型：
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作者：
Hayreh SS;Zimmerman MB
系统探讨视网膜中央静脉阻塞（CRVO）后视网膜和视盘的变化及其自然历史。该研究纳入了562例连续的CRVO患者[492例非缺血性（NI-CRVO）和89例缺血性CRVO (I-CRVO)]发病3个月内，首次和随访时的眼科评估包括记录视力、视野、详细的前段和眼底检查以及荧光素眼底血管造影。与NI-CRVO组相比，I-CRVO组的视网膜和亚内限制膜出血和视盘水肿最初更为明显（p<0.0001），并且需要更长的时间才能消退（p<0.015）。最初，I-CRVO组黄斑水肿比NI-CRVO组更明显（p<0.0001），但在消退时间上无显著差异（p=0.238）。黄斑视网膜上皮色素变性、浆液性黄斑脱离和视网膜周围静脉鞘在I-CRVO组的发生率高于NI-CRVO组（p<0.0001）。I-CRVO比NI-CRVO有更多的视网膜静脉充血（p=0.003）。荧光素眼底血管造影显示，I-CRVO患者荧光素渗漏、视网膜毛细血管扩张、毛细血管闭塞、毛细血管中央凹破裂明显多于NI-CRVO患者（p<0.0001）。I-CRVO的CRVO分辨率时间长于NI-CRVO （p<0.0001）。两种类型CRVO的特点和眼底表现的自然史不同。
To investigate systematically the retinal and optic disc changes in central retinal vein occlusion (CRVO) and their natural history. The study comprised 562 consecutive CRVO patients [492 non-ischemic (NI-CRVO) and 89 ischemic CRVO (I-CRVO) eyes] seen within 3 months of onset, Ophthalmic evaluation at initial and follow-up visits included recording visual acuity, visual fields, and detailed anterior segment and fundus examinations and fluorescein fundus angiography. Retinal and sub-internal limiting membrane hemorrhages, and optic disc edema in I-CRVO were initially more marked (p<0.0001), and took longer to resolve (p<0.015) than in NI-CRVO. Initially, macular edema was more marked in I-CRVO than NI-CRVO (p<0.0001), but did not significantly differ in resolution time (p=0.238). Macular retinal epithelial pigment degeneration, serous macular detachment, and retinal perivenous sheathing developed at a higher rate in I-CRVO than in NI-CRVO (p<0.0001). I-CRVO had more retinal venous engorgement than NI-CRVO (p=0.003). Fluorescein fundus angiography showed significantly more fluorescein leakage, retinal capillary dilatation, capillary obliteration, and broken capillary foveal arcade (p<0.0001) in I-CRVO than NI-CRVO. Resolution time of CRVO was longer for I-CRVO than NI-CRVO (p<0.0001). Characteristics and natural history of fundus findings in the two types of CRVO are different.