LIPIDS OF OCULAR TISSUES .8. EFFECTS OF ESSENTIAL FATTY-ACID DEFICIENCY ON PHOSPHOLIPIDS OF PHOTORECEPTOR MEMBRANES OF RAT RETINA
LIPIDS OF OCULAR TISSUES .8. EFFECTS OF ESSENTIAL FATTY-ACID DEFICIENCY ON PHOSPHOLIPIDS OF PHOTORECEPTOR MEMBRANES OF RAT RETINA
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DOI：
10.1016/0003-9861(72)90497-3
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发表时间：
1972-01-01
影响因子：
3.9
通讯作者：
MAUDE, MB
中科院分区：
文献类型：
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作者：
ANDERSON, RE;MAUDE, MB
处死以无脂或实验室饲料喂养 10 周的大鼠，切除其视网膜，并准备杆外节用于脂质分析。在磷脂组成方面没有发现差异，并且在这些光感受器膜的磷脂中的脂肪酸分布中仅观察到很小的差异。必需脂肪酸缺乏的常用指标 20:3ω9 在除视网膜和感光膜之外的所有检查组织中积累。由于大鼠感光膜每 9 天彻底更新一次，视网膜必须有一种机制来保存其丰富的 ω3 多不饱和脂肪酸供应。
Rats raised for 10 weeks on fat-free or lab chow diets were sacrificed, their retinas removed, and rod outer segments prepared for lipid analysis. No differences were found in the phospholipid composition and only small differences were observed in the fatty acid distribution in the phospholipids of these photoreceptor membranes. The usual indicator of essential fatty acid deficiency, 20:3ω9, accumulated in all of the tissues examined except the retina and the photoreceptor membranes. Since rat photoreceptor membranes are completely renewed every 9 days the retina must have a mechanism for conserving its abundant supply of ω3 polyunsaturates.