Mesenchymal stem cells and hypoxia: Where are we?
Mesenchymal stem cells and hypoxia: Where are we?
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DOI：
10.1016/j.mito.2014.07.005
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发表时间：
2014-11-01
期刊：
影响因子：
4.4
通讯作者：
Zhivotovsky, B.
中科院分区：
文献类型：
--
作者：
Buravkova, L. B.;Andreeva, E. R.;Zhivotovsky, B.
多能间充质基质细胞（MSC）参与组织完整性的组织和维护。间充质干细胞作为一种有前途的细胞治疗和再生医学工具也引起了人们的关注。然而，由于离体移植过程中极其恶劣的微环境引起的细胞损伤，它们的使用受到限制。组织库中 MSC 的微环境具有相当低的耗氧量，这表明 MSC 可能对氧限制具有很强的抵抗力。然而，积累的数据表明，间充质干细胞对缺氧条件的反应颇有争议，表现出破坏性和改善作用。在这里，我们试图总结关于不同持续时间和严重程度的低氧条件下间充质干细胞存活的最新知识，并阐明间充质干细胞对低氧影响的抵抗/敏感性机制。 (C) 2014 年 Elsevier B.V. 和线粒体研究协会。版权所有。
Multipotent mesenchymal stromal cells (MSCs) are involved in the organization and maintenance of tissue integrity. MSCs have also attracted attention as a promising tool for cell therapy and regenerative medicine. However, their usage is limited due to cell impairment induced by an extremely harsh microenvironment during transplantation ex vivo. The microenvironment of MSCs in tissue depots is characterized by rather low oxygen consumption, demonstrating that MSCs might be quite resistant to oxygen limitation. However, accumulated data revealed that the response of MSCs to hypoxic conditions is rather controversial, demonstrating both damaging and ameliorating effects. Here, we make an attempt to summarize recent knowledge on the survival of MSCs under low oxygen conditions of varying duration and severity and to elucidate the mechanisms of MSC resistance/sensitivity to hypoxic impact. (C) 2014 Elsevier B.V. and Mitochondria Research Society. All rights reserved.