Conserved Fungal LysM Effector Ecp6 Prevents Chitin-Triggered Immunity in Plants
Conserved Fungal LysM Effector Ecp6 Prevents Chitin-Triggered Immunity in Plants
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DOI：
10.1126/science.1190859
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发表时间：
2010-08-20
期刊：
影响因子：
56.9
通讯作者：
Thomma, Bart P. H. J.
中科院分区：
文献类型：
--
作者：
de Jonge, Ronnie;van Esse, H. Peter;Thomma, Bart P. H. J.
多细胞生物在识别病原体相关分子模式（PAMP）后激活免疫。几丁质是真菌细胞壁的主要成分，几丁质寡糖在植物和哺乳动物细胞中充当PAMP。微生物病原体递送效应蛋白以抑制PAMP触发的宿主免疫并建立感染。在这里，我们表明，含有LysM结构域的效应蛋白Ecp6的真菌植物病原体叶枝孢介导的毒性，通过扰动几丁质引发的宿主免疫。在感染期间，Ecp 6隔离从入侵菌丝的细胞壁释放的几丁质寡糖，以防止引发宿主免疫。这可能代表了真菌病原体抑制宿主免疫的常见策略，因为LysM效应子在真菌界中广泛保守。
Multicellular organisms activate immunity upon recognition of pathogen-associated molecular patterns (PAMPs). Chitin is the major component of fungal cell walls, and chitin oligosaccharides act as PAMPs in plant and mammalian cells. Microbial pathogens deliver effector proteins to suppress PAMP-triggered host immunity and to establish infection. Here, we show that the LysM domain-containing effector protein Ecp6 of the fungal plant pathogen Cladosporium fulvum mediates virulence through perturbation of chitin-triggered host immunity. During infection, Ecp6 sequesters chitin oligosaccharides that are released from the cell walls of invading hyphae to prevent elicitation of host immunity. This may represent a common strategy of host immune suppression by fungal pathogens, because LysM effectors are widely conserved in the fungal kingdom.