Biodistribution of anionic separated MDP complexes from different MDP preparations
Biodistribution of anionic separated MDP complexes from different MDP preparations
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DOI：
10.1007/bf00256939
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Å. Handeland;M. Lindegaard;D. Heggli
中科院分区：
文献类型：
--
作者：
Å. Handeland;M. Lindegaard;D. Heggli
用阴离子交换色谱法研究了从不同的MDP制剂中分离出的Tc-MDP配合物的生物分布。我们纳入了一家生产商的MDP制剂，其中含有抗坏血酸和龙胆酸作为稳定剂，另一家生产商的制剂中含有抗坏血酸。在大鼠中比较不同Tc-MDP复合物分离后的骨与软组织比率。似乎放射色谱的洗脱剖面可以指示制剂的生物分布。抗坏血酸和龙胆酸引起不同的洗脱谱，分离的不同复合物被证明具有不同的骨肌比。
The biodistributions of different, Tc-MDP complexes, separated from different MDP preparations by anionic exchange chromatography, were investigated. We included MDP preparations from one producer with both ascorbic and gentisic acid as stabilizing agent and one preparation with ascorbic acid from a second producer. Bone to soft tissue ratios, in rats were compared for the different Tc-MDP complexes separated. It seems that the elution profile of the radiochromatogram may indicate the biodistribution of the preparation. Ascorbic acid and gentisic acid caused different elution profiles and the different complexes isolated were demonstrated to have different bone to muscle ratios.