MR COLOR MAPPING OF MYELIN FIBER ORIENTATION
MR COLOR MAPPING OF MYELIN FIBER ORIENTATION
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DOI：
10.1097/00004728-199111000-00003
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发表时间：
1991-11-01
影响因子：
1.3
通讯作者：
LEBIHAN, D
中科院分区：
文献类型：
--
作者：
DOUEK, P;TURNER, R;LEBIHAN, D
大脑白质中水的扩散已被证明是各向异性的：垂直于纤维方向而不是平行于纤维方向测量时，水的流动性较低。此功能用于生成髓磷脂纤维方向的图像。使用对垂直方向分子扩散敏感的平面回波成像序列获得志愿者的冠状和矢状磁共振扩散图像。然后通过将这些图像组合在一起生成髓磷脂方向的颜色编码图像。发现白质束的方向与已知的解剖结构非常一致。髓磷脂纤维方向图可能为评估白质疾病提供新的视角。
Diffusion of water in brain white matter has been shown to be anisotropic: Water mobility is lower when measured perpendicular to the fiber direction rather than parallel to it. This feature was used to produce images of the myelin fiber orientation. Coronal and sagittal MR diffusion images were obtained in volunteers using an echo-planar imaging sequence sensitized to molecular diffusion in perpendicular directions. Color-coded images of myelin orientation were then generated by combining these images together. The orientation of the white matter tracts was found to be in excellent agreement with known anatomy. Myelin fiber orientation mapping may offer a new perspective to evaluate white matter disorders.