Prenatal programming of hypertension in the rat: effect of postnatal rearing.
Prenatal programming of hypertension in the rat: effect of postnatal rearing.
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作者：
Habib S;Zhang Q;Baum M
怀孕期间缺乏膳食蛋白质会导致后代成年后出现高血压。本研究检测了出生后饲养对雄性大鼠的血压和肾小球数量是否有影响，这些大鼠的母亲被喂食对照饮食或低蛋白饮食。新生儿在1日龄时与不同的母亲交叉寄养。出生后，所有哺乳期和断奶大鼠饲喂对照饲料。测量成年后代的血压和肾小球数量。与另一个对照母亲交叉饲养的对照大鼠的血压低于与另一个低蛋白母亲交叉饲养的低蛋白大鼠（133 ± 4对151 ± 4 mm Hg，p < 0.05），肾小球数量更多（28，388 ± 989对25，045 ± 851，p < 0.05）。从20%组的幼仔喂养的母亲，在怀孕期间喂养6%的饮食没有引起高血压或肾小球数量减少。然而，在怀孕期间喂养20%蛋白质饮食的母亲培养6%组导致血压和肾小球数量正常化。产前蛋白质缺乏引起的高血压和肾小球数量减少可以通过改善出生后的环境而正常化。
Dietary protein deprivation during pregnancy causes hypertension in offspring when they become adults. This study examined if postnatal rearing had an effect on blood pressure and glomerular number in male rats whose mothers were fed either a control diet or a low protein diet. Neonates were cross fostered at 1 day of age to a different mother. After birth, all nursing and weaned rats were fed a control diet. Blood pressure and glomerular number were measured in adult offspring. Control rats cross fostered to another control mother had a lower blood pressure than low protein rats cross fostered to another low protein mother (133 ± 4 vs. 151 ± 4 mm Hg, p < 0.05) and a greater number of glomeruli (28,388 ± 989 vs. 25,045 ± 851, p < 0.05). Fostering pups from the 20% group to mothers that were fed a 6% diet during pregnancy did not cause hypertension or a reduction in the number of glomeruli. However, fostering the 6% group on to mothers that were fed a 20% protein diet during pregnancy resulted in normalization of the blood pressure and number of glomeruli. The hypertension and reduced glomerular number resulting from prenatal dietary protein deprivation can be normalized by improving the postnatal environment.