Tribbles in acute leukemia
Tribbles in acute leukemia
复制标题
DOI：
10.1182/blood-2012-12-471300
复制
发表时间：
2013-05-23
期刊：
影响因子：
20.3
通讯作者：
Keeshan, Karen
中科院分区：
文献类型：
--
作者：
Liang, Kai Ling;Rishi, Loveena;Keeshan, Karen
哺乳动物Tribbles（Trib）家族丝氨酸/苏氨酸假激酶及其与急性白血病的致癌关联引起了越来越多的研究兴趣。本文就Trib基因在造血系统恶性肿瘤中的作用及其作为急性髓细胞白血病和急性淋巴细胞白血病治疗新靶点的潜力作一综述。我们讨论了在不同亚型的急性白血病中，Tribs作为中枢信号介质的作用，并提出抑制失调的Tribs信号可能是有益的治疗。
There is growing research interest in the mammalian Tribbles (Trib) family of serine/threonine pseudokinases and their oncogenic association with acute leukemias. This review is to understand the role of Trib genes in hematopoietic malignancies and their potential as targets for novel therapeutic strategies in acute myeloid leukemia and acute lymphoblastic leukemia. We discuss the role of Tribs as central signaling mediators in different subtypes of acute leukemia and propose that inhibition of dysregulated Trib signaling may be therapeutically beneficial.