Relationship between serum angiopoietin-2 level and perfusion CT paramet
Relationship between serum angiopoietin-2 level and perfusion CT paramet
复制标题
血清血管生成素2水平与灌注CT参数的关系
DOI：
10.1038/ajg.2011.175
复制
发表时间：
2011
影响因子：
9.8
通讯作者：
Yamam
中科院分区：
文献类型：
--
作者：
Tsuji Y;Kodama Y;Isoda H;Yamam
致编者：早期预测严重急性胰腺炎（SAP）的并发症，如多器官功能衰竭和胰腺坏死的发展，对于改善SAP患者的临床预后至关重要。人们已经努力建立预测SAP并发症的方法。灌注计算机断层扫描（CT）是预测胰腺坏死发展的一种很有前途的技术（1,2）。Whitcomb等人最近的研究(3)表明，入院时血清血管生成素-2 （ang2）升高可预测SAP患者的持续器官衰竭。ang2由受损血管产生并增加血管通透性(4)。ang2升高在器官衰竭发展中的作用及其与胰腺坏死的关系尚不清楚。因此，我们研究了SAP患者血清ang2水平与灌注CT参数（局部循环和体循环的替代品）之间的关系（1,2）。本研究得到了我们机构审查委员会的批准。所有患者均给予书面知情同意。2004年11月至2008年10月，11例SAP患者入院时采集血清，入院时行灌注CT检查。急性胰腺炎的严重程度通过亚特兰大标准和/或急性生理和慢性健康评估II评分进行评估。采用酶联免疫吸附法回顾性测定血清ang2水平。
To the Editor: Early prediction of complications of severe acute pancreatitis (SAP) such as multiple organ failure and development of pancreatic necrosis is essential to improve the clinical outcome of patients with SAP. Effort has been made to establish methods to predict complications of SAP. Perfusion computed tomography (CT) is a promising technique to predict development of pancreatic necrosis (1, 2). Recent study by Whitcomb et al.(3) showed that elevated serum angiopoietin-2 (Ang-2) on admission is predictive of persistent organ failure in patients with SAP. Ang-2 is produced by damaged vessels and increases vascular permeability (4). Role of elevated Ang-2 in development of organ failure and relationship with pancreatic necrosis is unclear. Therefore, we investigated the relationship between serum Ang-2 levels and perfusion CT parameters, surrogates of local and systemic circulation, in patients with SAP (1, 2).This study was approved by our institutional review board. All patients had given written informed consent. From November 2004 to October 2008, 11 patients with SAP whose serums were collected on admission and who underwent perfusion CT on admission were enrolled. Severity of acute pancreatitis was assessed by the Atlanta criteria and/or Acute Physiology and Chronic Health Evaluation II scores. Serum Ang-2 levels were measured on the stored sera in a retrospective manner by enzyme-linked immunosorbent assay.