WITHDRAWAL FROM MORPHINE OR AMPHETAMINE - DIFFERENT EFFECTS ON DOPAMINE IN THE VENTRAL-MEDIAL STRIATUM STUDIED WITH MICRODIALYSIS
WITHDRAWAL FROM MORPHINE OR AMPHETAMINE - DIFFERENT EFFECTS ON DOPAMINE IN THE VENTRAL-MEDIAL STRIATUM STUDIED WITH MICRODIALYSIS
复制标题
DOI：
10.1016/0006-8993(94)90206-2
复制
发表时间：
1994-07-04
期刊：
影响因子：
2.9
通讯作者：
ROBINSON, TE
中科院分区：
文献类型：
--
作者：
CRIPPENS, D;ROBINSON, TE
采用在体微透析技术研究了吗啡或苯丙胺慢性戒断对纹状体腹内侧区多巴胺（DA）神经传递的影响。苯丙胺戒断24小时对腹内侧纹状体DA的基础浓度没有影响。自发性吗啡戒断（24小时）与透析液中DA基础浓度的显著降低相关，但吗啡替代和纳洛酮促戒断后戒断症状的变化与透析液中DA浓度的变化无关。建议：（1）腹内侧纹状体中DA细胞外浓度与吗啡戒断症状之间的相关性可能并不表明存在必然的因果关系;（2）腹内侧纹状体中DA细胞外浓度的降低并不是药物戒断综合征的常见特征。
The effect of withdrawal from chronic morphine or amphetamine treatment on dopamine (DA) neurotransmission in the ventral-medial striatum was studied by use of in vivo microdialysis. There was no effect of 24 h of amphetamine withdrawal on the basal concentration of DA in the ventral-medial striatum. Spontaneous morphine withdrawal (24 h) was associated with a significant decrease in the basal concentration of DA in dialysate, but following morphine replacement and naloxone-precipitated withdrawal variations in withdrawal symptoms were not related to variations in the concentration of DA in dialysate. It is suggested that: (1) the correlation between the extracellular concentration of DA in the ventral-medial striatum and the symptoms of morphine withdrawal may not be indicative of a necessary, causal relationship; and (2) a decrease in the extracellular concentration of DA in the ventral-medial striatum is not a common feature of drug withdrawal syndromes.