The Hh pathway promotes cell apoptosis through Ci-Rdx-Diap1 axis
The Hh pathway promotes cell apoptosis through Ci-Rdx-Diap1 axis
复制标题
DOI：
10.1038/s41420-021-00653-3
复制
发表时间：
2021
影响因子：
7
通讯作者：
Zhan Meixiao
中科院分区：
文献类型：
--
作者：
Liu Bin;Ding Bin;Sun Bing;Liu Qingxin;Zhou Zizhang;Zhan Meixiao
Apoptosis is a strictly coordinated process to eliminate superfluous or damaged cells, and its deregulation leads to birth defects and.various human diseases. The regulatory mechanism underlying apoptosis still remains incompletely understood. To identify novel.components in apoptosis, we carry out a modifier screen and find that the Hh pathway aggravates Hid-induced apoptosis. In.addition, we reveal that the Hh pathway triggers apoptosis through its transcriptional target gene rdx, which encodes an E3.ubiquitin ligase. Rdx physically binds Diap1 to promote its K63-linked polyubiquitination, culminating in attenuating Diap1−Dronc.interaction without affecting Diap1 stability. Taken together, our findings unexpectedly uncover the oncogenic Hh pathway is able.to promote apoptosis through Ci-Rdx-Diap1 module, raising a concern to choose Hh pathway inhibitors as anti-tumor drugs.
