Effects of milk proteins supplementation in older adults undergoing resistance training: A meta-analysis of randomized control trials
Effects of milk proteins supplementation in older adults undergoing resistance training: A meta-analysis of randomized control trials
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DOI：
10.1007/s12603-017-0899-y
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发表时间：
2018-02-01
影响因子：
5.8
通讯作者：
Qin, L. -Q.
中科院分区：
文献类型：
--
作者：
Hidayat, K.;Chen, G. -C.;Qin, L. -Q.
背景：老年人经历与年龄相关的生理变化，影响体重和身体成分。一般来说，营养和运动已被确定为骨骼肌中蛋白质合成的有效刺激物。牛奶蛋白质是所有必需氨基酸的良好来源，可能是一种理想的蛋白质来源，以促进进行阻力训练的老年人的肌肉耐力。然而，几项随机对照试验（RCT）得出了牛奶蛋白补充剂与阻力训练相结合对体重和组成的影响的混合结果。研究方法：在PubMed、Web of Science和科克伦数据库中检索文献，以评价截至2016年9月接受抗阻训练的老年人（年龄= 60岁）补充乳蛋白对体重和成分的影响。使用随机效应模型计算效应量的合并估计值和95%置信区间（CI）。结果：最终分析包括10项随机对照试验，涉及574名受试者（平均年龄范围为60至80.8岁）。总的来说，牛奶蛋白补充和阻力训练的组合对脂肪质量（0.30，95%CI：-0.25，0.86 kg）或体重（1.02，95%CI：-0.01，2.04 kg）没有显著影响。然而，观察到牛奶蛋白补充剂与阻力训练配对对去脂质量的积极影响（0.74，95% CI 0.30，1.17 kg）。在包括超过55名参与者（0.73，95% CI 0.30，1.16 kg）的研究中以及在招募患有衰老相关疾病的参与者（1.60，95% CI 0.92，2.28 kg）的研究中观察到更大的无脂体重增加。没有统计学证据表明这些研究存在发表偏倚。结论：我们的研究结果提供的证据表明，补充牛奶蛋白，结合阻力训练，是有效地引起老年人的无脂肪体重增加。
Background: Older adults experience age-related physiological changes that affect body weight and body composition. In general, nutrition and exercise have been identified as potent stimulators of protein synthesis in skeletal muscle. Milk proteins are excellent sources of all the essential amino acids and may represent an ideal protein source to promote muscle anabolism in older adults undergoing resistance training. However, several randomized control trials (RCTs) have yielded mixed results on the effects of milk proteins supplementation in combination with resistance training on body weight and composition. Methods: PubMed, Web of Science and Cochrane databases were searched for literature that evaluated the effects of milk proteins supplementation on body weight and composition among older adults (age = 60 years) undergoing resistance training up to September 2016. A random-effects model was used to calculate the pooled estimates and 95% confidence intervals (CIs) of effect sizes. Results: The final analysis included 10 RCTs involving 574 participants (mean age range from 60 to 80.8 years). Overall, the combination of milk proteins supplementation and resistance training did not have significant effect on fat mass (0.30, 95% CI -0.25, 0.86 kg) or body weight (1.02, 95% CI: -0.01, 2.04 kg). However, a positive effect of milk proteins supplementation paired with resistance training on fat-free mass was observed (0.74, 95% CI 0.30, 1.17 kg). Greater fat-free mass gains were observed in studies that included more than 55 participants (0.73, 95% CI 0.30, 1.16 kg), and in studies that enrolled participants with aging-related medical conditions (1.60, 95% CI 0.92, 2.28 kg). There was no statistical evidence of publication bias among the studies. Conclusion: Our findings provide evidence that supplementation of milk protein, in combination with resistance training, is effective to elicit fat-free mass gain in older adults.