Metals in fungal virulence.
Metals in fungal virulence.
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DOI：
10.1093/femsre/fux050
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发表时间：
2018-01-01
影响因子：
11.3
通讯作者：
Brunke S
中科院分区：
文献类型：
--
作者：
Gerwien F;Skrahina V;Kasper L;Hube B;Brunke S
金属是生命所必需的，它们在感染微生物与宿主之间的斗争中发挥着核心作用。事实上，微生物致病的一个重要方面是“营养免疫”，其中金属被宿主主动限制（或在该术语的扩展定义中，局部富集）以阻碍微生物生长和毒力。因此，真菌进化出了复杂的调控网络，吸收和解毒系统的基本金属，如铁，锌，铜，镍和锰。这些系统通常与细菌系统有着根本的不同，但即使在真菌病原体中，我们也可以找到共同和独特的解决方案来维持金属稳态。因此，我们在这里比较了不同真菌物种中用于不同金属的常见和物种特异性机制-重点关注重要的人类病原体，例如白色念珠菌、烟曲霉或新型隐球菌，但也研究了模式真菌，例如酿酒酵母或A. nidulans作为深入研究的基本原则的例子。这些我们现有知识的直接比较表明，我们有一个很好的理解模式真菌病原体如何采取铁或锌，但还有很多要了解其他金属和特定的适应个别物种，而不是利用新的抗真菌策略的知识。致病真菌需要金属才能生存并在宿主中引起疾病。它们复杂的调节、吸收和解毒系统往往是唯一适应体内条件的系统。本文综述了人类真菌病原体的金属稳态机制。
Metals are essential for life, and they play a central role in the struggle between infecting microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the ‘nutritional immunity’, in which metals are actively restricted (or, in an extended definition of the term, locally enriched) by the host to hinder microbial growth and virulence. Consequently, fungi have evolved often complex regulatory networks, uptake and detoxification systems for essential metals such as iron, zinc, copper, nickel and manganese. These systems often differ fundamentally from their bacterial counterparts, but even within the fungal pathogens we can find common and unique solutions to maintain metal homeostasis. Thus, we here compare the common and species-specific mechanisms used for different metals among different fungal species—focusing on important human pathogens such as Candida albicans, Aspergillus fumigatus or Cryptococcus neoformans, but also looking at model fungi such as Saccharomyces cerevisiae or A. nidulans as well-studied examples for the underlying principles. These direct comparisons of our current knowledge reveal that we have a good understanding how model fungal pathogens take up iron or zinc, but that much is still to learn about other metals and specific adaptations of individual species—not the least to exploit this knowledge for new antifungal strategies. Pathogenic fungi require metals to survive and cause disease in the host. Their complex regulatory, uptake and detoxification systems are often uniquely adapted to conditions in vivo. This review compares and contrasts metal homeostasis mechanisms of human fungal pathogens.
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影响因子：
5.4
作者：
Bruhn KW;Spellberg B
通讯作者：
Spellberg B
影响因子：
6.4
作者：
Cadieux, Brigitte;Lian, Tianshun;Kronstad, James W.
通讯作者：
Kronstad, James W.
影响因子：
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作者：
Baek, Yong-Un;Li, Mingchun;Davis, Dana A.
通讯作者：
Davis, Dana A.
影响因子：
--
作者：
Amich, Jorge;Vicentefranqueira, Rocio;Antonio Calera, Jose
通讯作者：
Antonio Calera, Jose
影响因子：
30.3
作者：
Botella H;Peyron P;Levillain F;Poincloux R;Poquet Y;Brandli I;Wang C;Tailleux L;Tilleul S;Charrière GM;Waddell SJ;Foti M;Lugo-Villarino G;Gao Q;Maridonneau-Parini I;Butcher PD;Castagnoli PR;Gicquel B;de Chastellier C;Neyrolles O
通讯作者：
Neyrolles O