LHRH and analogs: contraceptive and therapeutic considerations.
LHRH and analogs: contraceptive and therapeutic considerations.
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LHRH 和类似物：避孕和治疗注意事项。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
R. Jones
中科院分区：
文献类型：
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作者：
A. Corbin;F. Bex;R. Jones
本文综述了LHRH类似物（激动剂和拮抗剂）在避孕、避孕和治疗方面的研究进展。它利用了大量来自两性临床前和临床研究的数据，特别是加强了天然LHRH在治疗一系列不孕症中的应用。这种促生育方法与利用激动剂作为避孕药的矛盾的抗生殖作用形成对比，并作为性早熟、子宫内膜异位症和前列腺癌和乳腺癌等卵巢依赖性肿瘤的新疗法。LHRH拮抗剂由于其独特的抗LHRH性质，目前正在评估其作为抗生育剂以及用于上述类固醇依赖性病理。
This paper reviews the developments of the LHRH analogs (agonists and antagonists) in terms of their conceptive, contraceptive and therapeutic utility. It draws upon the mass of data derived from pre-clinical and clinical studies, in both sexes, reinforcing, in particular, the application of the natural LHRH in treating a spectrum of infertile conditions. This profertility approach is contrasted by utilization of the paradoxical antireproductive effect of the agonists as contraceptives, and as a novel therapy for precocious puberty, endometriosis and hormone-dependent tumors, such as prostatic and mammary carcinoma. The LHRH antagonists, by virtue of their singular anti-LHRH properties, are presently being evaluated as antifertility agents, and for the above steroid-dependent pathologies.