EFFICACY OF AN INACTIVATED FELINE CALICIVIRUS (FCV) VACCINE AGAINST CHALLENGE WITH UNITED-KINGDOM FIELD STRAINS AND ITS INTERACTION WITH THE FCV CARRIER STATE
EFFICACY OF AN INACTIVATED FELINE CALICIVIRUS (FCV) VACCINE AGAINST CHALLENGE WITH UNITED-KINGDOM FIELD STRAINS AND ITS INTERACTION WITH THE FCV CARRIER STATE
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DOI：
10.1016/s0034-5288(18)32431-7
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发表时间：
1982-01-01
影响因子：
2.4
通讯作者：
WOOLDRIDGE, MJA
中科院分区：
文献类型：
--
作者：
GASKELL, CJ;GASKELL, RM;WOOLDRIDGE, MJA
评估了猫杯状病毒（FCV）FS2株灭活疫苗对3种英国FCV野外毒株攻毒的效力。与未接种动物相比，接种猫的平均临床评分（根据攻毒后21天内每天记录的体征数量计算）较低，但差异无统计学显著性。攻毒后3周内，所有猫均排泄FCV，在此期间，接种和未接种动物之间的病毒脱落天数无差异。记录疫苗接种和攻毒后FCV血清中和抗体滴度的变化。在研究的第二部分，证明了接种疫苗和攻毒猫成为FCV携带者，然后感染易感接触动物的能力。
The efficacy of an inactivated vaccine derived from feline calicivirus (FCV) strain FS2 was assessed against challenge with 3 UK field strains of FCV. The mean clinical score, calculated on the number of signs recorded per day over 21 days after challenge, was lower for vaccinated cats when compared to unvaccinated animals though the difference was not statistically significant. All cats excreted FCV throughout the 3 wk following challenge and there was no difference in the number of days of virus shedding during this period between vaccinated and unvaccinated animals. The development of FCV serum neutralizing antibody titers following vaccination and challenge was recorded. In the 2nd part of the study the ability of vaccinated and challenged cats to become FCV carriers and then infect susceptible in-contact animals was demonstrated.