Conceptual Shifts Needed to Understand the Dynamic Interactions of Genes, Environment, Epigenetics, Social Processes, and Behavioral Choices
Conceptual Shifts Needed to Understand the Dynamic Interactions of Genes, Environment, Epigenetics, Social Processes, and Behavioral Choices
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DOI：
10.2105/ajph.2013.301221
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发表时间：
2013-10-01
影响因子：
12.7
通讯作者：
Jackson, Robert T.
中科院分区：
文献类型：
--
作者：
Jackson, Fatimah L. C.;Niculescu, Mihai D.;Jackson, Robert T.
公共卫生领域的社会和行为研究往往与潜在的遗传、环境和表观遗传事件产生的深刻但经常被忽视的生物学影响密切相关。生命科学、社会科学和行为科学之间的动态相互作用在解决复杂的疾病和障碍以及制定有效的补救策略方面往往未得到充分的重视和利用。我们采用案例研究的形式，举例说明如何将遗传学、环境学和表观遗传学数据纳入其中，从而通过扩大此类研究的参数来增强社会和行为健康研究，我们强调了基因-环境相互作用和表观遗传学作为表型变化来源的重要作用，以及作为生命科学、社会科学和行为科学之间的桥梁，在发展稳健的跨学科分析中的重要作用。
Social and behavioral research in public health is often intimately tied to profound, but frequently neglected, biological influences from underlying genetic, environmental, and epigenetic events. The dynamic interplay between the life, social, and behavioral sciences often remains underappreciated and underutilized in addressing complex diseases and disorders and in developing effective remediation strategies.Using a case-study format, we present examples as to how the inclusion of genetic, environmental, and epigenetic data can augment social and behavioral health research by expanding the parameters of such studies, adding specificity to phenotypic assessments, and providing additional internal control in comparative studies.We highlight the important roles of gene-environment interactions and epigenetics as sources of phenotypic change and as a bridge between the life and social and behavioral sciences in the development of robustinterdisciplinaryanalyses.