THROMBIN ACCUMULATION IN BRAINS OF PATIENTS WITH ALZHEIMERS-DISEASE
THROMBIN ACCUMULATION IN BRAINS OF PATIENTS WITH ALZHEIMERS-DISEASE
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DOI：
10.1016/0304-3940(92)90065-f
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发表时间：
1992-11-09
影响因子：
2.5
通讯作者：
MCGEER, PL
中科院分区：
文献类型：
--
作者：
AKIYAMA, H;IKEDA, K;MCGEER, PL
凝血酶在阿尔茨海默病（AD）患者和年龄匹配的对照组的脑组织中进行了检测。阳性染色仅限于对照组的血管和残余血浆，但也存在于老年斑、一些弥漫性淀粉样沉积物和AD的神经纤维缠结中。用纯化的人凝血酶吸收抗体可以消除阳性染色，但用凝血酶原吸收则不能消除阳性染色。这些数据表明，凝血酶原形成凝血酶可能发生在AD脑。
Thrombin was detected immunohistochemically in brain tissue of Alzheimer's disease (AD) patients and age-matched controls. Positive staining was restricted to vessels and residual plasma in controls but was also present in senile plaques, some diffuse amyloid deposits and neurofibrillary tangles in AD. Positive staining was abolished by absorption of antibody with purified human thrombin but not by absorption with prothrombin. The data suggest that thrombin formation from prothrombin probably takes place in AD brain.