CD1B RESTRICTS THE RESPONSE OF HUMAN CD4-8- LYMPHOCYTES-T TO A MICROBIAL ANTIGEN
CD1B RESTRICTS THE RESPONSE OF HUMAN CD4-8- LYMPHOCYTES-T TO A MICROBIAL ANTIGEN
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DOI：
10.1038/360593a0
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发表时间：
1992-12-10
期刊：
影响因子：
64.8
通讯作者：
BRENNER, MB
中科院分区：
文献类型：
--
作者：
PORCELLI, S;MORITA, CT;BRENNER, MB
人类1号染色体上CD1基因座编码的分子(参考文献CD1分子与人类6号染色体上主要组织相容性复合体(MHC)基因编码的抗原提呈分子在结构上的相似性(参考文献3，4，34，35)，提示CD1可能是一个独立于MHC1，5，6编码的抗原提呈分子家族。本文报道CD1-8-AlphabetaTCR+T细胞对结核分枝杆菌的增殖和细胞毒反应可受CD1b的限制。这些T细胞对结核分枝杆菌的反应似乎不涉及MHC编码分子，但完全依赖于抗原提呈细胞CD1b的表达，并涉及与MHC II类限制性抗原提呈相似的抗原处理要求。据我们所知，这些结果为CD1分子的抗原提呈功能提供了第一个直接证据，并表明CD1家族在细胞免疫中对微生物病原体的免疫起到了作用。
MOLECULES encoded by the human CD1 locus on chromosome 1 (ref. 33) are recognized by selected CD4-8- T-cell clones expressing either alphabeta or gammadelta T-cell antigen receptors1,2. The known structural resemblance of CD1 molecules to antigen-presenting molecules encoded by major histocompatibility complex (MHC) genes on human chromosome 6 (refs 3, 4, 34, 35), suggested that CD1 may represent a family of antigen-presenting molecules separate from those encoded in the MHC1,5,6. Here we report that the proliferative and cytotoxic responses of human CD4-8-alphabetaTCR+ T cells specific for Mycobacterium tuberculosis can be restricted by CD1b, one of the four identified protein products of the CD1 locus. The responses of these T cells to M. tuberculosis seemed not to involve MHC encoded molecules, but were absolutely dependent on the expression of CD1b by the antigen-presenting cell and involved an antigen processing requirement similar to that seen in MHC class II-restricted antigen presentation. These results provide, to our knowledge, the first direct evidence for the proposed antigen-presenting function of CD1 molecules and suggest that the CD1 family plays a role in cell-mediated immunity to microbial pathogens.