Targeted nanomedicines: effective treatment modalities for cancer, AIDS and brain disorders
Targeted nanomedicines: effective treatment modalities for cancer, AIDS and brain disorders
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DOI：
10.2217/17435889.4.1.105
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发表时间：
2009-01-01
期刊：
影响因子：
5.5
通讯作者：
Singh, S.
中科院分区：
文献类型：
--
作者：
Muthu, M. S.;Singh, S.
纳米医学领域的新技术有望开发出创新产品作为靶向给药方法。用于治疗癌症、艾滋病和脑部疾病的各种药物的靶向药物递送是纳米医学具有主要作用和需求的主要研究领域。本文综述了近年来新兴的靶向纳米药物（聚合物纳米颗粒、固体脂质纳米颗粒、聚合物胶束、树枝状大分子、脂质体、金纳米颗粒和磁性纳米颗粒）和能够结合靶向药物递送和成像的多功能载体（聚合物胶束、树枝状大分子和磁性纳米颗粒）在药学领域的应用。与这些纳米药物相关的重大毒性问题也在这里进行了探讨。
Novel technology in the nanomedicine field is expected to develop innovative products as targeted drug-delivery approaches. Targeted drug delivery of various drugs for the treatment of cancer, AIDS and brain disorders is the primary research area in which nanomedicines have a major role and need. This review is concerned with emerging targeted nanomedicines (polymeric nanoparticles, solid lipid nanoparticles, polymeric micelles, dendrimers, liposomes, gold nanoparticles and magnetic nanoparticles) and multifunctional carriers capable of combining targeted drug delivery and imaging (polymeric micelles, dendrimers and magnetic nanoparticles) in the field of pharmaceutical applications. The significant toxicity issues associated with these nanomedicines are also explored here.