Oral squamous cell carcinoma: an analysis of 1,564 cases showing advances in early detection.
Oral squamous cell carcinoma: an analysis of 1,564 cases showing advances in early detection.
复制标题
口腔鳞状细胞癌：对 1,564 例病例的分析显示早期检测的进展。
DOI：
10.2334/josnusd.52.267
复制
发表时间：
2010
影响因子：
1.9
通讯作者：
S. de Sousa
中科院分区：
文献类型：
--
作者：
L. Marocchio;J. Lima;F. Sperandio;L. Corrêa;S. de Sousa
本研究旨在检测过去40年圣保罗市牙科学校诊断的口腔鳞状细胞癌（OSCC）病例数据中可能存在的差异。检索了1960年至2008年间诊断为OSCC的患者记录。整个时期分为四个时间段。共审查了1 564个案件。分析的变量包括：性别、年龄、种族、解剖部位、病变持续时间和病变大小。采用卡方检验进行统计学分析。总体而言，男性比女性受影响更大（3：1），但当比较第一个和最后一个时间段时，比例显著下降（5.8：1至2.8：1）。在过去的时间段内，观察到80岁以上患者的口腔鳞状细胞癌发病率显著增加。牙龈是最受影响的部位，但下唇受累的频率在最后一个时间段增加。关于诊断时的病变大小和症状持续时间，第一个和最后一个时间段之间存在显著差异。在研究的最后几年，发现了较小的病变，病变发展的时间较短。这些发现支持了乐观的观点，即近年来，圣保罗市的早期口腔癌检测导致了早期诊断。
The present study aimed to detect possible differences in the data of oral squamous cell carcinomas (OSCC) cases diagnosed in a Dental School in São Paulo city over the last 40 years. The records of patients diagnosed as having OSCC between the years 1960 and 2008 were retrieved. The whole period was divided into four time periods. A total of 1,564 cases were reviewed. The variables analyzed were: sex, age, race, anatomical site, lesion duration, and lesion size. The chi-square test was used for statistical analysis. Overall, males were more affected than females (3:1), but when comparing the first and last time periods, the ratio decreased significantly (5.8:1 to 2.8:1). A significant increase in the rate of OSCC in patients over 80 years was observed in the last time periods. The gingiva was the most affected site, but the frequency of lower lip involvement increased in the last time period. Regarding lesion size and duration of symptoms at the time of diagnosis, there was a significant difference between the first and last time periods. Smaller lesions were found and the time of lesion development was shorter in the last few years of the study. These findings support the optimistic view that, in recent years, earlier diagnosis has resulted from early oral cancer detection in São Paulo city.