Candidate molecular markers for histological diagnosis of early hepatocellular carcinoma
Candidate molecular markers for histological diagnosis of early hepatocellular carcinoma
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DOI：
10.1159/000122603
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发表时间：
2008-01-01
期刊：
影响因子：
4.6
通讯作者：
Du, Wenlin
中科院分区：
文献类型：
--
作者：
Sakamoto, Michiie;Mori, Taisuke;Du, Wenlin
肝细胞癌（Hepatocellular carcinoma，HCC）是最常见的恶性肿瘤之一。肝癌主要发生在慢性病变的肝脏，如：G. B和C型肝炎感染后。对这些高危患者进行密切随访，通过影像学诊断发现越来越多的可疑小病变。它们现在被广泛认为是前体或早期HCC，并被分类为发育不良结节或早期HCC。例如，这些病变缺乏普通HCC的典型成像和组织学，并且不显示甲胎蛋白和PIVKA-II的血清标志物升高。对这些病变的分子分析将有助于开发早期HCC客观组织学诊断的分子标志物，并可能开发新的早期HCC血清标志物。已有研究表明，HSP 70、CAP 2、磷脂酰肌醇蛋白聚糖3和谷氨酰胺合成酶可作为早期肝癌的分子标志物。进一步的分析，预计将评估其在常规病理诊断，包括活检诊断，也作为早期检测肝癌的血清标志物的有用性。版权所有（c）2008 S. Karger AG，巴塞尔。
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. HCC occurs mainly in chronically diseased livers, e. g. following hepatitis B and C infection. These highrisk patients are closely followed up, and increasing numbers of small equivocal lesions are detected by imaging diagnosis. They are now widely recognized as precursor or early-stage HCCs and are classified as dysplastic nodule or early HCC. These lesions lack typical imaging and histology of ordinary HCC and do not show elevated serum markers of alpha - fetoprotein and PIVKA-II, for example. Molecular analysis of these lesions would help to develop molecular markers for objective histological diagnosis of early HCC and possibly new serum markers for early detection of HCC. It has been reported that HSP70, CAP2, glypican 3 and glutamine synthetase could serve as molecular markers for early HCC. Further analysis is expected to evaluate their usefulness in routine pathological diagnosis including biopsy diagnosis and also as serum markers for early detection of HCC. Copyright (c) 2008 S. Karger AG, Basel.