Tracking the dose distribution in radiation therapy by accounting for variable anatomy
Tracking the dose distribution in radiation therapy by accounting for variable anatomy
复制标题
DOI：
10.1088/0031-9155/49/5/010
复制
发表时间：
2004-03-07
影响因子：
3.5
通讯作者：
Van Dyk, J
中科院分区：
文献类型：
--
作者：
Schaly, B;Kempe, JA;Van Dyk, J
这项研究的目标是通过跟踪传递到患者体内移动的组织元素(体素)的剂量分布，计算放射治疗患者在考虑不同解剖结构的情况下每天和累积接收的剂量分布。非线性图像配准技术(即，薄板样条线)与传统的治疗计划系统一起使用，以组合针对在治疗期间进行的每个3D计算机断层扫描(CT)研究计算的剂量分布。对于一例临床前列腺癌病例，我们证明了由于体素在单个部分和15个累积部分中的系统性运动，存在显著的局部剂量差异。与计划剂量相比，第一次放疗后直肠、膀胱和精囊的最大正剂量差分别为29%、2%和24%。累积15次后，直肠、膀胱和精囊的最大正剂量差分别为计划剂量的23%、32%和18%。给出了控制点布置的灵敏度分析。这种方法提供了对实际投放剂量的重要了解，并有可能提供定量信息，作为适应性放射治疗的指南。
The goal of this research is to calculate the daily and cumulative dose distribution received by the radiotherapy patient while accounting for variable anatomy, by tracking the dose distribution delivered to tissue elements (voxels) that move within the patient. Non-linear image registration techniques (i.e., thin-plate splines) are used along with a conventional treatment planning system to combine the dose distributions computed for each 3D computed tomography (CT) study taken during treatment. For a clinical prostate case, we demonstrate that there are significant localized dose differences due to systematic voxel motion in a single fraction as well as in 15 cumulative fractions. The largest positive dose differences in rectum, bladder and seminal vesicles were 29%, 2% and 24%, respectively, after the first fraction of radiation treatment compared to the planned dose. After 15 cumulative fractions, the largest positive dose differences in rectum, bladder and seminal vesicles were 23%, 32% and 18%, respectively, compared to the planned dose. A sensitivity analysis of control point placement is also presented. This method provides an important understanding of actual delivered doses and has the potential to provide quantitative information to use as a guide for adaptive radiation treatments.