Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening.
Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening.
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DOI：
10.1016/j.addr.2015.07.004
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发表时间：
2016-01-15
影响因子：
16.1
通讯作者：
George SC
中科院分区：
文献类型：
--
作者：
Kurokawa YK;George SC
准确检测心脏毒性的能力在新药开发中变得越来越重要。自从人类多能干细胞衍生的心肌细胞出现以来，研究人员已经探索了它们在创建体外药物筛选平台中的用途。最近，人们越来越关注创建心脏的3D微生理模型作为检测心脏毒性化合物的工具。通过重现天然心脏中存在的复杂微环境，与临床前药物筛选的当前标准相比，心脏微生理系统有可能提供更准确的药理学反应。本文综述了近年来在建立先进的人类心脏模型方面所取得的进展，包括各种细胞和细胞外成分对心脏功能的重要性和贡献。
The ability to accurately detect cardiotoxicity has become increasingly important in the development of new drugs. Since the advent of human pluripotent stem cell-derived cardiomyocytes, researchers have explored their use in creating an in vitro drug screening platform. Recently, there has been increasing interest in creating 3D microphysiological models of the heart as a tool to detect cardiotoxic compounds. By recapitulating the complex microenvironment that exists in the native heart, cardiac microphysiological systems have the potential to provide a more accurate pharmacological response compared to current standards in preclinical drug screening. This review aims to provide an overview on the progress made in creating advanced models of the human heart, including the significance and contributions of the various cellular and extracellular components to cardiac function.