INHIBITION OF DNA AND RNA POLYMERASE REACTIONS BY CHLOROQUINE
INHIBITION OF DNA AND RNA POLYMERASE REACTIONS BY CHLOROQUINE
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DOI：
10.1073/pnas.54.2.521
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发表时间：
1965-01-01
影响因子：
11.1
通讯作者：
YIELDING, KL
中科院分区：
文献类型：
--
作者：
COHEN, SN;YIELDING, KL
目前的研究已经检查了氯喹及其某些类似物对DNA依赖的核酸酶促合成的影响。结果表明，氯喹可抑制DNA和RNA聚合酶反应，显然是其与DNA引物相互作用的直接结果。这些观察结果为氯喹的作用提供了可能的分子基础，并表明该化合物和其他取代的喹啉可能有助于研究DNA在生物过程中的功能。关于其中某些观察结果的初步报告已在其他地方提出。
The present studies have examined the effects of chloroquine and certain of its analogues on the DNA-dependent enzymic synthesis of nucleic acids. The results indicate that chloroquine can inhibit both the DNA and the RNA polymerase reactions, apparently as a direct consequence of its interaction with the DNA primer. The observations provide a possible molecular basis for chloroquine action, and suggest that this compound and other substituted quinolines might be useful in studying the functions of DNA in biological processes. Preliminary reports of certain of these observations have been presented elsewhere.