Auditory Hallucinations and the Brain's Resting-State Networks: Findings and Methodological Observations.
Auditory Hallucinations and the Brain's Resting-State Networks: Findings and Methodological Observations.
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DOI：
10.1093/schbul/sbw078
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发表时间：
2016-09
影响因子：
6.6
通讯作者：
Jardri R
中科院分区：
文献类型：
--
作者：
Alderson-Day B;Diederen K;Fernyhough C;Ford JM;Horga G;Margulies DS;McCarthy-Jones S;Northoff G;Shine JM;Turner J;van de Ven V;van Lutterveld R;Waters F;Jardri R
近年来，人们越来越关注改变大脑静息态网络（RSN）来解释各种精神病理学的潜力。 RSN 为幻觉提供了一个有趣的新解释框架，幻觉可能以不同的方式和人群发生，但人们对它仍然知之甚少。国际幻觉研究联盟 (ICHR) 的这项合作报告了静息态改变与幻听 (AH) 之间联系的证据，并对这一领域使用的方法进行了批判性评估。在报告中，我们描述了 AH（精神分裂症和非临床个体）的静息连接功能磁共振成像的结果，并将其与神经生理学研究、结构 MRI 和幻视 (VH) 研究的结果进行比较。在 AH 中，各种研究表明左半球听觉和语言区域的静息连接差异，以及与认知控制和显着性相关的默认模式网络和 RSN 的非典型相互作用。由于后者在 VH 研究中也很明显，这表明了幻觉的域一般机制以及不同感觉区域 RSN 的模态特异性变化。然而，我们还观察到当前文献中方法论的高度异质性，影响了研究之间进行清晰比较的能力。为了解决这个问题，我们为静息状态和幻觉的未来研究提供了一些方法建议和选择。
In recent years, there has been increasing interest in the potential for alterations to the brain’s resting-state networks (RSNs) to explain various kinds of psychopathology. RSNs provide an intriguing new explanatory framework for hallucinations, which can occur in different modalities and population groups, but which remain poorly understood. This collaboration from the International Consortium on Hallucination Research (ICHR) reports on the evidence linking resting-state alterations to auditory hallucinations (AH) and provides a critical appraisal of the methodological approaches used in this area. In the report, we describe findings from resting connectivity fMRI in AH (in schizophrenia and nonclinical individuals) and compare them with findings from neurophysiological research, structural MRI, and research on visual hallucinations (VH). In AH, various studies show resting connectivity differences in left-hemisphere auditory and language regions, as well as atypical interaction of the default mode network and RSNs linked to cognitive control and salience. As the latter are also evident in studies of VH, this points to a domain-general mechanism for hallucinations alongside modality-specific changes to RSNs in different sensory regions. However, we also observed high methodological heterogeneity in the current literature, affecting the ability to make clear comparisons between studies. To address this, we provide some methodological recommendations and options for future research on the resting state and hallucinations.