Comparison of three rodent neuropathic pain models
Comparison of three rodent neuropathic pain models
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DOI：
10.1007/bf02450318
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发表时间：
1997-02-01
影响因子：
2
通讯作者：
Chung, JM
中科院分区：
文献类型：
--
作者：
Kim, KJ;Yoon, YW;Chung, JM
为了确定神经病理性疼痛的不同动物模型的特征，我们使用相同的行为测试方法比较了先前开发的三种大鼠模型。这些模型包括：(1)坐骨神经松弛结扎(CCI)所致的慢性压迫性损伤；(2)部分坐骨神经的紧密结扎(PSL)；(3)脊神经的紧密结扎(SNL)。对代表神经病理性疼痛不同成分的行为体征的时间进程以及外科交感神经切除术的效果进行了比较。总体而言，所有三种周围神经损伤方法都会产生持续疼痛和诱发疼痛的行为迹象，时间进程相似。然而，在不同的模型中，每个疼痛成分的大小都有相当大的差异。SNL损伤组的机械性痛觉异常体征最大，CCI模型组最小。另一方面，代表持续疼痛的行为迹象在CCI模型中比在其他两个模型中更加突出。虽然三种模型的神经病理性疼痛的行为体征在交感神经切除后都有减少的趋势，但这种变化在SNL模型中最为明显。本研究的结果表明，所测试的三种大鼠模型具有不同的特点，但都是有用的神经病理性疼痛模型，可能代表了不同人群的人类神经病理性疼痛患者。
To characterize various animal models of neuropathic pain, we compared three previously developed rat models using the same behavioral testing methods. These models involve: (I) chronic constriction injury by loose ligation of the sciatic nerve (CCI); (2) tight ligation of the partial sciatic nerve (PSL); and (3) tight ligation of spinal nerves (SNL). Comparisons were made for the time course of behavioral signs representing various components of neuropathic pain as well as for the effects of surgical sympathectomy. In general, all three methods of peripheral nerve injury produced behavioral signs of both ongoing and evoked pain with similar time courses. However, there was a considerable difference in the magnitude of each pain component between models. Signs of mechanical allodynia were largest in the SNL injury and smallest in the CCI model. On the other hand, behavioral signs representing ongoing pain were much more prominent in the CCI model than in the other two. Although the behavioral signs of neuropathic pain tended to decrease after sympathectomy in all three models, the change was most evident in the SNL model. The results of the present study suggest that the three rat models tested have contrasting features, yet all are useful neuropathic pain models, possibly representing different populations of human neuropathic pain patients.