Epigenetic marks as the link between environment and development: examination of the associations between attachment, socioeconomic status, and methylation of the SLC6A4 gene.
Epigenetic marks as the link between environment and development: examination of the associations between attachment, socioeconomic status, and methylation of the SLC6A4 gene.
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DOI：
10.1002/brb3.480
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发表时间：
2016-07
影响因子：
3.1
通讯作者：
Hamilton S
中科院分区：
文献类型：
--
作者：
Jones-Mason K;Allen IE;Bush N;Hamilton S
表观遗传过程充当环境和个体发展之间的联系。这项试点研究检查了社会经济地位 (SES)、附着性和血清素转运蛋白基因 (SLC6A4) 启动子区域甲基化之间的关联。在 100 名青少年晚期确定了依恋分类和 SLC6A4 甲基化。我们假设 (1) SES 会与甲基化相互作用，以预测成人依恋访谈中较高的未解决损失 (UL) 或创伤分数； (2) 在SES中，依恋未解决的参与者的甲基化水平低于有组织或安全的参与者； (3) 在未解决的分类中，SES 可以预测甲基化。结果显示，较低的甲基化和低 SES 与较高的 UL 相关，较高的甲基化和低 SES 与较高的未解决创伤相关。在 SES 中，未解决的参与者的甲基化水平低于有组织的参与者。在未解决类别中，低SES未解决参与者的甲基化水平高于中/上SES参与者。 SES 与安全和有组织类别中的甲基化无关。这些结果表明依恋关系的质量可能会影响表观遗传过程。
Epigenetic processes act as a link between environment and individual development. This pilot study examined the association between socioeconomic status (SES), attachment, and methylation of the promoter region of the serotonin transporter gene (SLC6A4). Attachment classification and SLC6A4 methylation was determined in 100 late adolescents. We hypothesized that (1) SES would interact with methylation to predict higher unresolved loss (UL) or trauma scores on the Adult Attachment Interview; (2) across SES, participants with unresolved attachment would have lower levels of methylation than organized or secure participants; and (3) within the unresolved classification, SES would predict methylation. Results showed that lower methylation and low‐SES were associated with higher UL, and higher methylation and low‐SES were associated with higher unresolved trauma. Across SES, unresolved participants had lower levels of methylation than organized participants. Within the unresolved category, low‐SES unresolved participants had higher levels of methylation than mid/upper‐SES participants. SES was unrelated to methylation within the secure and organized categories. These results suggest that the quality of attachment relationships may impact epigenetic processes.