High susceptibility of human dendritic cells to invasion by the intracellular pathogens Brucella suis, Brucella abortus, and Brucella melitensis
High susceptibility of human dendritic cells to invasion by the intracellular pathogens Brucella suis, Brucella abortus, and Brucella melitensis
复制标题
DOI：
10.1128/iai.73.12.8418-8424.2005
复制
发表时间：
2005-12-01
影响因子：
3.1
通讯作者：
Gross, A
中科院分区：
文献类型：
--
作者：
Billard, E;Cazevieille, C;Gross, A
布氏杆菌属的细菌能够在巨噬细胞内生存和增殖。因为它们在遗传学上与巨噬细胞密切相关，所以髓样树突状细胞（DC）构成布鲁氏菌的潜在靶。在这里，我们报告说，树突状细胞显示出很大的易感性布鲁氏菌感染。因此，树突状细胞可能作为一个水库，是重要的布鲁氏菌细菌在其宿主内的发展。
Bacteria from the Brucella genus are able to survive and proliferate within macrophages. Because they are phylogenetically closely related to macrophages, myeloid dendritic cells (DCs) constitute potential targets for Brucella bacteria. Here we report that DCs display a great susceptibility to Brucella infection. Therefore, DCs might serve as a reservoir and be important for the development of Brucella bacteria within their host.