Rapid Response to the Combination of Lenvatinib and Sintilimab in a Pancreatic Acinar Cell Carcinoma Patient With Elevated Alpha-Fetoprotein: A Case Report.
Rapid Response to the Combination of Lenvatinib and Sintilimab in a Pancreatic Acinar Cell Carcinoma Patient With Elevated Alpha-Fetoprotein: A Case Report.
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乐伐替尼和信迪利单抗联合治疗甲胎蛋白升高的胰腺腺泡细胞癌患者的快速反应：病例报告
DOI：
10.3389/fonc.2021.692480
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zou Z
中科院分区：
文献类型：
--
作者：
Qin L;Shen J;Yang Y;Zou Z
一位48岁的女性被诊断为转移性胰腺腺泡细胞癌(PACC)，甲胎蛋白(AFP)显著升高，这是公认的但不常见的PACC特征。由于她拒绝化疗，接受了lenvatinib和sintilimab的联合治疗(lenvatinib 8 mg，口服，qd；sintilimab 100 mg，静脉注射糖耐量试验，q21d)，这使肿瘤显著缩小，无进展生存期延长(>；21个月)。这项研究是第一次报道和描述PACC对抗血管生成剂和免疫治疗的联合治疗表现出良好的反应。
A 48-year old woman was diagnosed with metastatic pancreatic acinar cell carcinoma (PACC) and with a marked elevation in alpha-fetoprotein (AFP), this being a recognized but uncommon feature of PACC. As she refused chemotherapy, the combined therapy of lenvatinib and sintilimab (lenvatinib 8 mg, orally, qd; and sintilimab 100 mg, intravenous glucose tolerance test, q21d) was given, which conferred significant tumor shrinkage and long progression-free survival (>21 months). This study is the first report and description of a PACC demonstrating favorable response to the combination therapy of an antiangiogenic agent and immunotherapy.
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DOI：
10.1158/1078-0432.ccr-15-2412
发表时间：
2016-06-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Martens A;Wistuba-Hamprecht K;Geukes Foppen M;Yuan J;Postow MA;Wong P;Romano E;Khammari A;Dreno B;Capone M;Ascierto PA;Di Giacomo AM;Maio M;Schilling B;Sucker A;Schadendorf D;Hassel JC;Eigentler TK;Martus P;Wolchok JD;Blank C;Pawelec G;Garbe C;Weide B
通讯作者：
Weide B
影响因子：
3.4
作者：
Hernando-Calvo, A.;Garcia-Alvarez, A.;Munoz-Couselo, E.
通讯作者：
Munoz-Couselo, E.
影响因子：
45.3
作者：
Holen, KD;Klimstra, DS;Saltz, LB
通讯作者：
Saltz, LB
影响因子：
45.3
作者：
Sheng, Xinan;Yan, Xieqiao;Guo, Jun
通讯作者：
Guo, Jun
影响因子：
5.2
作者：
Shalata W;Iraqi M;Bhattacharya B;Fuchs V;Roisman LC;Cohen AY;Massalha I;Yakobson A;Prasad M;Elkabets M;Porgador A;Peled N
通讯作者：
Peled N