The association of nocturia with incident falls in an elderly community-dwelling cohort.
The association of nocturia with incident falls in an elderly community-dwelling cohort.
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DOI：
10.1111/j.1742-1241.2009.02326.x
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发表时间：
2010-04
影响因子：
2.6
通讯作者：
Johnson TM 2nd
中科院分区：
文献类型：
--
作者：
Vaughan CP;Brown CJ;Goode PS;Burgio KL;Allman RM;Johnson TM 2nd
以社区老年人为样本，研究夜尿症与跌倒事件的关系。阿拉巴马大学伯明翰分校的老龄化研究是一项对1000名居住在美国社区的老年人进行的前瞻性队列研究，旨在调查与行动不便有关的因素。受试者是从分层随机抽样的联邦医疗保险受益人中招募的，包括同等数量的黑人女性、黑人男性、白人女性和白人男性。在基线时评估夜尿症，在基线时和每6个月评估跌倒，总共进行36个月的随访。692名受试者(平均年龄74.5±6.2岁，女性48%，黑人52%)在基线前12个月内没有跌倒。在这692人中，214人(30.9%)报告在随后的三年中至少下降了一次。在非校正分析中，夜间尿失禁三次或三次以上与跌倒相关(RR=1.27，95%CI(1.01-1.60))。经多因素Logistic回归分析，夜尿三次或以上与跌倒风险增加相关(RR=1.28，(1.02-1.59))。在一项种族多元化的、以社区为基础的样本中，在前一年没有跌倒的老年男性和女性中，多变量分析表明，每晚夜尿三次或更多次与三年内发生意外事件的风险增加28%相关。虽然这项研究比以前的报告有几个优势(纵向随访、基于绩效的功能测量、基于总体的抽样)，但因果关系无法确定。作为减少跌倒风险的多成分计划的一部分，需要进一步的研究来确定减少夜尿症的治疗的影响。
To examine the association of nocturia with incident falls in a population-based sample of community-dwelling elderly persons. The University of Alabama at Birmingham Study of Aging is a prospective cohort study of 1000 community-dwelling older adults in the USA designed to examine factors associated with impaired mobility. Subjects were recruited from a stratified, random sample of Medicare beneficiaries to include equal numbers of black women, black men, white women and white men. Nocturia was assessed at baseline and falls were assessed at baseline and every six months for a total of 36 months of follow-up. 692 individuals (mean age 74.5±6.2, 48% female, 52% black) did not fall in the 12 months prior to baseline. Of these 692, 214 (30.9%) reported falling at least once during the subsequent three years. In unadjusted analysis, three or more nightly episodes of nocturia was associated with an incident fall (RR=1.27, 95% CI (1.01-1.60)). After multivariable logistic regression, three or more episodes of nocturia was associated with an increased risk of falling (RR=1.28, (1.02-1.59)). In a racially diverse, community-based sample of older men and women who had not fallen in the previous year, nocturia three or more times a night was associated in multivariable analysis with a 28% increased risk of an incident fall within three years. While this study has several advantages over previous reports (longitudinal follow-up, performance-based measures of function, population-based sampling), causality cannot be ascertained. Further research is needed to ascertain the impact of treatments to reduce nocturia as part of a multi-component program to reduce fall risk.